Precision medicine has the potential to profoundly improve the practice of medicine.
However, the advances required will take time to implement. Genetics is already being used …

Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks
between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous …

Determining the pathogenicity of genetic variants is a critical challenge, and functional
assessment is often the only option. Experimentally characterizing millions of possible …

Widely used as anticancer and immunosuppressive agents, thiopurines have narrow
therapeutic indices owing to frequent toxicities, partly explained by TPMT genetic …

Purpose Mercaptopurine (MP) is the mainstay of curative therapy for acute lymphoblastic
leukemia (ALL). We performed a genome-wide association study (GWAS) to identify …

As precision medicine becomes increasingly relevant in healthcare, the field of
pharmacogenomics (PGx) also continues to gain prominence in the clinical setting. Leading …

The slow rate at which pharmacogenetic tests are being adopted in clinical practice is partly
due to the lack of specific guidelines on how to adjust medications on the basis of the …

Although the field of pharmacogenetics has existed for decades, practioners have been slow
to implement pharmacogenetic testing in clinical care. Numerous publications describe the …

Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …

Improved supportive care, more precise risk stratification, and personalized chemotherapy
based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and …