Eukaryotes are divided into two major compartments: the nucleus where RNA is synthesized
and processed, and the cytoplasm, where mRNA is translated into proteins. Although many …

Long noncoding RNAs (lncRNAs) are emerging as key parts of multiple cellular pathways,
but their modes of action and how these are dictated by sequence remain unclear. lncRNAs …

Nuclear retention of incompletely spliced or mature mRNAs emerges as a novel, previously
underappreciated layer of gene regulation, which enables the cell to rapidly respond to …

Regulation of alternative splicing is one of the most efficient mechanisms to enlarge the
proteomic diversity in eukaryotic organisms. Many viruses hijack the splicing machinery …

Introns are removed by the spliceosome, a large macromolecular complex composed of five
ribonucleoprotein subcomplexes (U snRNPs). The U1 snRNP, which binds to 5ʹ splice …

Hepatitis B virus (HBV) causes hepatitis, which progresses to fatal liver diseases and
remains a global health problem. Current treatments for chronic hepatitis B are unable to …

Most current models of mRNA nuclear export in vertebrate cells assume that an mRNA must
have specialized signals in order to be exported from the nucleus. Under such a scenario …

Alternative splicing is universally accredited for expanding the information encoded within
the transcriptome. In recent years, several tightly regulated alternative splicing events have …

After human immunodeficiency virus type 1 (HIV-1) was identified in the early 1980s,
intensive work began to understand the molecular basis of HIV-1 gene expression …

All lentiviruses encode the accessory protein Rev, whose main biological function is to
mediate the nuclear export of unspliced and incompletely spliced viral transcripts by binding …