The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Down syndrome (DS), also known as trisomy 21, is the most common genetic cause of
intellectual disability (ID). Although ID can be mild, the average intelligence quotient is in the …

Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting
from early life stages. Accumulating evidence shows that the phenotypic features of the DS …

Amyloid precursor protein (APP) is a member of the APP family of proteins, and different
enzymatic processing leads to the production of several derivatives that are shown to have …

Cognitive disability is an unavoidable feature of Down syndrome (DS), a genetic disorder
due to the triplication of human chromosome 21. DS is associated with alterations of …

Amyloid precursor protein (APP), secretase enzymes, and amyloid beta (Aβ) have been
extensively studied in the context of Alzheimer's disease (AD). Despite this, the function of …

Intellectual disability is the unavoidable hallmark of Down syndrome (DS), with a heavy
impact on public health. Reduced neurogenesis and impaired neuron maturation are …

Amyloid precursor protein (APP) is implicated in neural development as well as in the
pathology of Alzheimer's disease (AD); however, its biological function still remains unclear …

Alzheimer's disease (AD) is the most common cause of dementia globally. AD is a
progressive neurodegenerative disorder, eventually manifesting as severe cognitive …

Down syndrome (DS) is the most common non-lethal genetic condition that affects
approximately 1 in 700 births in the United States of America. DS is characterized by …