Biology and pathophysiology of symptomatic neuromas

CD Hwang, YAJ Hoftiezer, FV Raasveld… - Pain, 2024 - journals.lww.com
Neuromas are a substantial cause of morbidity and reduction in quality of life. This is not
only caused by a disruption in motor and sensory function from the underlying nerve injury …

[HTML][HTML] Mechanisms of action of neuropeptide Y on stem cells and its potential applications in orthopaedic disorders

JQ Wu, N Jiang, B Yu - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
Musculoskeletal disorders are the leading causes of disability and result in reduced quality
of life. The neuro-osteogenic network is one of the most promising fields in orthopaedic …

Fracture hematoma micro-architecture influences transcriptional profile and plays a crucial role in determining bone healing outcomes

A Woloszyk, ZK Tuong, L Perez, L Aguilar… - Biomaterials …, 2022 - Elsevier
The hematoma that forms between broken fragments of bone serves as a natural fibrin
scaffold, and its removal from the defect site delays bone healing. The hypothesis of this …

Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform

DI Silva, BP Santos, J Leng, H Oliveira… - Cell death & disease, 2017 - nature.com
Innervation by the sensory nervous system plays a key role in skeletal development and in
orchestration of bone remodeling and regeneration. However, it is unclear how and in which …

Crosstalk between sensory nerves and cancer in bone

T Yoneda, M Hiasa, T Okui - Current osteoporosis reports, 2018 - Springer
Abstract Purpose of Review Sensory nerves (SNs) richly innervate bone and are a
component of bone microenvironment. Cancer metastasis in bone, which is under the …

Skeletal phenotype of the neuropeptide Y knockout mouse

NKY Wee, BP Sinder, S Novak, X Wang, C Stoddard… - Neuropeptides, 2019 - Elsevier
Neuropeptide Y (NPY) is involved in multiple processes such as behavior, energy and bone
metabolism. Previous studies have relied on global NPY depletion to examine its effects on …

Early life stress exacerbates bone resorption and inhibits anxiety‐like behaviour induced by apical periodontitis in rats

MC Bertolini Botelho, LTA Cintra… - International …, 2023 - Wiley Online Library
Aim To evaluate the influence of the early life stress (ELS) on the severity of the apical
periodontitis (AP) in Wistar rats. Methodology Forty male Wistar rats were divided into four …

Effects of early life stress on bone homeostasis in mice and humans

K Wuertz-Kozak, M Roszkowski, E Cambria… - International journal of …, 2020 - mdpi.com
Bone pathology is frequent in stressed individuals. A comprehensive examination of
mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In …

Bone-nerve crosstalk: a new state for neuralizing bone tissue engineering—A mini review

LA Damiati, M El Soury - Frontiers in Medicine, 2024 - frontiersin.org
Neuro bone tissue engineering is a multidisciplinary field that combines both principles of
neurobiology and bone tissue engineering to develop innovative strategies for repairing and …

Axonal outgrowth, neuropeptides expression and receptors tyrosine kinase phosphorylation in 3D organotypic cultures of adult dorsal root ganglia

E Neto, CJ Alves, L Leitão, DM Sousa, IS Alencastre… - PloS one, 2017 - journals.plos.org
Limited knowledge from mechanistic studies on adult sensory neuronal activity was
generated, to some extent, in recapitulated adult in vivo 3D microenvironment. To fill this gap …