Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

Although stroke is a frequent cause of permanent disability, our ability to promote stroke
recovery is limited. Here, we design a small-molecule stroke recovery promoting agent that …

Lipids are key factors in regulating membrane fusion. Lipids are not only structural
components to form membranes but also active catalysts for vesicle fusion and …

Synaptotagmin-1 is a vesicular protein and Ca2+ sensor for Ca2+-dependent exocytosis.
Ca2+ induces synaptotagmin-1 binding to its own vesicle membrane, called the cis …

Neurotransmitters are stored in small membrane-bound vesicles at synapses; a subset of
synaptic vesicles is docked at release sites. Fusion of docked vesicles with the plasma …

Vesicle fusion induces neurotransmitter release, orchestrated by synaptotagmin-1 (Syt-1) as
a Ca2+ sensor. However, the precise molecular mechanisms of Syt-1 remain controversial …

Genetic analyses of Schizophrenia (SCZ) patients have identified thousands of risk factors.
In silico protein-protein interaction (PPI) network analysis has provided strong evidence that …

SNARE proteins drive vesicle fusion and neurotransmitters release. Given that exocytosis is
fast, and vesicle docking is tight, SNARE proteins are likely pre-assembled before fusion …

Innovation and renovation: FEBS Open Bio in 2023 - Wright - 2023 - FEBS Open Bio - Wiley
Online Library Skip to Article Content Skip to Article Information FEBS Press FEBS Press …

Neuronal communication depends on the rapid release of neurotransmitters through Ca2+-
triggered synaptic vesicle exocytosis. Synaptotagmin-1 (Syt1) acts as the Ca2+ sensor for …