The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

Receptor tyrosine kinases (RTKs) are single-span transmembrane receptors in which
relatively conserved intracellular kinase domains are coupled to divergent extracellular …

Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with
seven different activating ligands shaping cell signaling in distinct ways. Using …

Human epidermal growth factor receptor (HER) 2 (HER2) is overexpressed in 20–30% of
breast cancers. HER2 is a preferred target for treating HER2-positive breast cancer …

The epidermal growth factor receptor (EGFR) regulates key processes of cell biology,
including proliferation, survival, and differentiation during development, tissue homeostasis …

Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive
fibrosis, ultimately leading to end‐stage renal disease. Although many studies have …

LH acts on periovulatory granulosa cells by activating the PKA pathway as well as other cell
signaling cascades to increase the transcription of specific genes necessary for ovulation …

Breast, prostate, pancreatic, colorectal, lung, and head and neck cancers exploit
deregulated signaling by ErbB family receptors and their ligands, EGF family peptide growth …

The androgen receptor (AR) mediates the physiologic and pathophysiologic effects of
androgens including sexual differentiation, prostate development, and cancer progression …

Collective metastasis is defined as the cohesive migration and metastasis of multicellular
tumor cell clusters. Disrupting various cell adhesion genes markedly reduces cluster …