Activity has an important role in refining synaptic connectivity during development, in part
through'Hebbian'mechanisms such as long-term potentiation and long-term depression …

Patterned, spontaneous activity occurs in many developing neural circuits, including the
retina, the cochlea, the spinal cord, the cerebellum and the hippocampus, where it provides …

The positive-feedback nature of Hebbian plasticity can destabilize the properties of neuronal
networks. Recent work has demonstrated that this destabilizing influence is counteracted by …

In vitro cultured neuronal networks coupled to microelectrode arrays (MEAs) constitute a
valuable experimental model for studying changes in the neuronal dynamics at different …

The zebrafish is a leading model for studies of vertebrate development and genetics. Its
embryonic motor behaviors are easy to assess (eg for mutagenic screens), the embryos …

Neurotransmitters are essential for interneuronal signalling, and the specification of
appropriate transmitters in differentiating neurons has been related to intrinsic neuronal …

Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous
system, where it plays essential roles in the refinement of neural connections. By blocking or …

At specific stages of development, nerve and muscle cells generate spontaneous electrical
activity that is required for normal maturation of intrinsic excitability and synaptic connectivity …

Development of precise neural circuitry is traditionally thought to involve two separate
phases. In the early activity-independent phase, neurons develop distinct phenotypes …

Spontaneous neuronal activity has been detected in many parts of the developing vertebrate
nervous system. Recent studies suggest that this activity depends on properties that are …