Hypercholesterolemia is a major risk factor for cardiovascular disease. Cholesterol
homeostasis in the body is governed by the interplay between absorption, synthesis, and …

Recently, it has been questioned whether elevated levels of circulating plant sterols
increase the risk of coronary heart disease (CHD). To date, no definitive conclusions …

Phytosterolaemia (sitosterolaemia) is a recessively inherited metabolic condition in which
the absorption of both cholesterol and plant‐derived cholesterol‐like molecules at the gut is …

This review integrates historical biochemical and modern genetic findings that underpin our
understanding of the low-density lipoprotein (LDL) dyslipidemias that bear on human …

Cholesterol absorption and synthesis contribute to maintaining cholesterol homeostasis.
Several physiological and therapeutic factors affect cholesterol homeostasis, including …

Recent insights in the role of ATP-binding cassette (ABC) transporters ABCG5 and ABCG8,
the discovery of ezetimibe, the first approved direct cholesterol absorption inhibitor, as well …

BACKGROUND: Cardiac conduction, as assessed by electrocardiographic PR interval and
QRS duration, is an important electrophysiological trait and a determinant of arrhythmia risk …

Structural data on ABCG5/G8 and ABCG2 reveal a unique molecular architecture for
subfamily G ATP‐binding cassette (ABCG) transporters and disclose putative substrate …

Background: Plant sterol (PS) supplementation is increasingly accepted as a dietary strategy
to lower plasma cholesterol concentrations. However, information is scarce about the effect …

The absorption efficiency of cholesterol is closely correlated to dietary phytosterol content
and determined by genetic factors. The ATP-binding cassette (ABC) transporters ABCG5 …