The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome

N Salmeri, P Viganò, P Cavoretto, R Marci… - Reviews in endocrine …, 2024 - Springer
Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive
disorders with a significant impact on the health and quality of life of women affected. A …

The emerging therapeutic potential of kisspeptin and neurokinin B

B Patel, K Koysombat, EG Mills, J Tsoutsouki… - Endocrine …, 2024 - academic.oup.com
Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

[HTML][HTML] Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research

V Sobrino, MS Avendano, C Perdices-Lopez… - Frontiers in …, 2022 - Elsevier
In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Kisspeptin in the prediction of pregnancy complications

J Tsoutsouki, B Patel, AN Comninos… - Frontiers in …, 2022 - frontiersin.org
Kisspeptin and its receptor are central to reproductive health acting as key regulators of the
reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator …

The role of kisspeptin in the pathogenesis of pregnancy complications: a narrative review

M Szydełko-Gorzkowicz… - International Journal of …, 2022 - mdpi.com
Kisspeptins are the family of neuropeptide products of the KISS-1 gene that exert the
biological action by binding with the G-protein coupled receptor 54 (GPR54), also known as …

Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk

E Reshetnikov, M Churnosova, Y Reshetnikova… - International Journal of …, 2024 - mdpi.com
We aimed to explore the potential link of maternal age at menarche (mAAM) gene
polymorphisms with risk of the fetal growth restriction (FGR). This case (FGR)–control (FGR …

Kisspeptin as a predictor of miscarriage: a systematic review

PHA Silva, LGM Romao, NPA Freitas… - The Journal of …, 2023 - Taylor & Francis
Objective A highly accurate serum marker for predicting viable pregnancy needs to be
developed. Recent studies have demonstrated that kisspeptin is a potential biomarker for …

[HTML][HTML] Kisspeptin signalling and its correlation with placental ultrastructure and clinical outcomes in pregnant South African women with obesity and gestational …

E Musa, E Salazar-Petres, M Vatish, N Levitt… - Placenta, 2024 - Elsevier
Introduction Gestational diabetes mellitus (GDM) is a major pregnancy metabolic disorder
and is strongly linked with obesity. Kisspeptin is a hormone that increases several thousand …

Endocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized …

A Abbara, M Ufer, C Voors-Pette, L Berman, M Ezzati… - Fertility and …, 2024 - Elsevier
Background Kisspeptin is an essential regulator of hypothalamic gonadotropin-releasing
hormone release and is required for physiological ovulation. Native kisspeptin-54 can …

The role of KNDy neurons in human reproductive health

A Oride, H Kanasaki - Endocrine Journal, 2024 - jstage.jst.go.jp
In the early 2000s, metastin, an endogenous ligand for G protein-coupled receptor 54
(GPR54), was discovered in human placental extracts. In 2003, GPR54 receptor mutations …