Distributions of exons and introns in the human genome

MK Sakharkar, VTK Chow, P Kangueane - In silico biology, 2004 - content.iospress.com
The human genome is revisited using exon and intron distribution profiles. The 26,564
annotated genes in the human genome (build October, 2003) contain 233,785 exons and …

Advances in the exon–intron database (EID)

V Shepelev, A Fedorov - Briefings in bioinformatics, 2006 - academic.oup.com
Investigation of exon–intron gene structures is a non-trivial task due to enormous
expansions of the eukaryotic genomes, great variety of gene forms, and the imperfectness in …

The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing

Y Brody, N Neufeld, N Bieberstein, SZ Causse… - PLoS …, 2011 - journals.plos.org
RNA processing events that take place on the transcribed pre-mRNA include capping,
splicing, editing, 3′ processing, and polyadenylation. Most of these processes occur co …

Messenger RNA surveillance and the evolutionary proliferation of introns

M Lynch, A Kewalramani - Molecular biology and evolution, 2003 - academic.oup.com
The mechanisms responsible for the proliferation and subsequent stabilization of introns
within the eukaryotic lineage have remained elusive. In the early stages of eukaryotic …

Species-specific variation of alternative splicing and transcriptional initiation in six eukaryotes

H Nagasaki, M Arita, T Nishizawa, M Suwa, O Gotoh - Gene, 2005 - Elsevier
The genome-wide detection of alternative splicing and transcriptional initiation (ASTI) was
conducted in six eukaryotes (human, mouse, fruit fly, nematode, cress and rice) whose …

Signatures of domain shuffling in the human genome

H Kaessmann, S Zöllner, A Nekrutenko… - Genome research, 2002 - genome.cshlp.org
To elucidate the role of exon shuffling in shaping the complexity of the human
genome/proteome, we have systematically analyzed intron phase distributions in the coding …

Identification of minimal eukaryotic introns through GeneBase, a user-friendly tool for parsing the NCBI Gene databank

A Piovesan, M Caracausi, M Ricci, P Strippoli… - DNA …, 2015 - academic.oup.com
We have developed GeneBase, a full parser of the National Center for Biotechnology
Information (NCBI) Gene database, which generates a fully structured local database with …

An analysis on gene architecture in human and mouse genomes

MK Sakharkar, BS Perumal, KR Sakharkar… - In silico …, 2005 - content.iospress.com
A comparative genome analysis on exon-intron distribution profiles is performed for human
and mouse genomes to deduce similarities and differences between them. Interestingly …

Joule heating-induced dispersion in open microfluidic electrophoretic cytometry

J Vlassakis, AE Herr - Analytical chemistry, 2017 - ACS Publications
While protein electrophoresis conducted in capillaries and microchannels offers high-
resolution separations, such formats can be cumbersome to parallelize for single-cell …

Computational searches for splicing signals

XHF Zhang, CS Leslie, LA Chasin - Methods, 2005 - Elsevier
The removal of introns from pre-mRNA requires as an initial event the accurate molecular
recognition of the proper exon–intron borders. It is now evident that RNA sequence …