Protein design: From the aspect of water solubility and stability
Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …
sequence and 3D-conformation. Their manipulation represents important aspects of the …
Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies
Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs)
are tremendous, the design and discovery of new candidates remain a time and cost …
are tremendous, the design and discovery of new candidates remain a time and cost …
Developability assessment at early-stage discovery to enable development of antibody-derived therapeutics
W Zhang, H Wang, N Feng, Y Li, J Gu… - Antibody …, 2023 - academic.oup.com
Developability refers to the likelihood that an antibody candidate will become a
manufacturable, safe and efficacious drug. Although the safety and efficacy of a drug …
manufacturable, safe and efficacious drug. Although the safety and efficacy of a drug …
Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
T Kandola, S Venkatesan, J Zhang, BT Lerbakken… - Elife, 2023 - elifesciences.org
A long-standing goal of amyloid research has been to characterize the structural basis of the
rate-determining nucleating event. However, the ephemeral nature of nucleation has made …
rate-determining nucleating event. However, the ephemeral nature of nucleation has made …
Protein misfolding and related human diseases: A comprehensive review of toxicity, proteins involved, and current therapeutic strategies
AN Khan, RH Khan - International Journal of Biological Macromolecules, 2022 - Elsevier
Most of the cell's chemical reactions and structural components are facilitated by proteins.
But proteins are highly dynamic molecules, where numerous modifications or changes in the …
But proteins are highly dynamic molecules, where numerous modifications or changes in the …
Lysozyme amyloid fibril: Regulation, application, hazard analysis, and future perspectives
Y Chen, Q Liu, F Yang, H Yu, Y Xie, W Yao - International Journal of …, 2022 - Elsevier
Self-assembly of misfolded proteins into ordered fibrillar aggregates known as amyloid
results in various human diseases. However, more and more proteins, whether in human …
results in various human diseases. However, more and more proteins, whether in human …
Self-assembling peptides: Structure, function, in silico prediction and applications
A Vahedifar, J Wu - Trends in Food Science & Technology, 2022 - Elsevier
Background Food proteins are natural sources of self-assembling peptides (SAPs) which
could form self-assembled nanostructures, including definite (eg, fibrils and nanotubes) and …
could form self-assembled nanostructures, including definite (eg, fibrils and nanotubes) and …
Exploring the sequence features determining amyloidosis in human antibody light chains
The light chain (AL) amyloidosis is caused by the aggregation of light chain of antibodies
into amyloid fibrils. There are plenty of computational resources available for the prediction …
into amyloid fibrils. There are plenty of computational resources available for the prediction …
[HTML][HTML] Accelerating therapeutic protein design with computational approaches toward the clinical stage
Therapeutic protein, represented by antibodies, is of increasing interest in human medicine.
However, clinical translation of therapeutic protein is still largely hindered by different …
However, clinical translation of therapeutic protein is still largely hindered by different …
Structural, kinetic, and thermodynamic aspects of insulin aggregation
Given the significance of protein aggregation in proteinopathies and the development of
therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the …
therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the …