Transforming growth factor‐β (TGF‐β) plays a complex role in lung cancer pathophysiology,
initially acting as a tumor suppressor by inhibiting early‐stage tumor growth. However, its …

Accumulating evidence has indicated that pre-mRNA splicing plays critical roles in a variety
of physiological processes, including development of multiple diseases. In particular …

Background The distant metastasis of cancer cells is a risk factor for tumor lethality and poor
prognosis in non-small-cell lung carcinoma (NSCLC). Increased SOX9 expression has been …

Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is a
major challenge for clinicians and patients with non-small cell lung cancer (NSCLC). Serine …

Cancer metastasis is the main cause of mortality associated with non-small-cell lung cancer
(NSCLC), accounting for up to 70% of deaths among patients. The mechanisms underlying …

It has been reported that the transcription factor activating enhancer-binding protein 4
(TFAP4) is upregulated and associated with an aggressive phenotype in several cancers …

Alternative splicing and polyadenylation represent two major steps in pre‐mRNA‐
processing, which ensure proper gene expression and diversification of human …

Long non‐coding RNAs (lncRNAs) play significant roles in the pathogenesis of various
cancers, including lung cancer. In this study, we aimed to investigate the biological function …

Autotaxin (ATX), also known as ENPP2, is the key enzyme in lysophosphatidic acid (LPA)
production. LPA acts on its receptors on the cell membrane to promote cell proliferation and …

Cisplatin and other platinum-based compounds are frequently used to treat breast cancer,
but their utility is severely compromised by drug resistance. Many genes dictating drug …