3′-Deoxy-3′-18F-fluorothymidine positron emission tomography as an early predictor of disease progression in patients with advanced and metastatic pancreatic …

A Challapalli, T Barwick, RA Pearson… - European journal of …, 2015 - Springer
Abstract Purpose 3′-Deoxy-3′-18 F-fluorothymidine (FLT) positron emission tomography
(PET) has limited utility in abdominal imaging due to high physiological hepatic uptake of …

The value of 18F-FLT PET for detecting second primary cancers and distant metastases in head and neck cancer patients

H Hoshikawa, T Kishino, T Mori… - Clinical Nuclear …, 2013 - journals.lww.com
Objective Diagnostic efficacy of 18 F-FLT PET was compared with that of 18 F-FDG PET
regarding second primary cancers and distant metastases of head and neck squamous cell …

Monitoring response to transarterial chemoembolization in hepatocellular carcinoma using 18F-fluorothymidine PET

R Sharma, M Inglese, S Dubash, H Lu… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Accurate disease monitoring is essential after transarterial chemoembolization (TACE) in
hepatocellular carcinoma (HCC) because of the potential for profound adverse events and …

3′-Deoxy-3'-18F-Fluorothymidine and 18F-Fluorodeoxyglucose positron emission tomography for the early prediction of response to Regorafenib in patients with …

JE Kim, SY Chae, JH Kim, HJ Kim, TW Kim… - European Journal of …, 2019 - Springer
Purpose The purpose of this study was to evaluate the value of 3′-deoxy-3′-18 F-
fluorothymidine (18 F-FLT) and 18 F-fluorodeoxyglucose (18 F-FDG) positron emission …

[HTML][HTML] The Role of 18F-FLT PET/CT in Assessing Early Response to Transarterial Radioembolization and Chemoembolization in Patients with Primary and …

D Nak, NÖ Küçük, EC Çelebioğlu… - Molecular Imaging …, 2022 - ncbi.nlm.nih.gov
Objectives: Metastases and primary malignancies are common in the liver. Local ablative
applications such as transarterial chemoembolization (TACE), and transarterial …

FLT-PET for early response evaluation of colorectal cancer patients with liver metastases: a prospective study

MB Mogensen, A Loft, M Aznar, T Axelsen, B Vainer… - EJNMMI research, 2017 - Springer
Abstract Background Fluoro-L-thymidine (FLT) is a positron emission tomography/computed
tomography (PET/CT) tracer which reflects proliferative activity in a cancer lesion. The main …

Molecular imaging of aurora kinase A (AURKA) expression: Synthesis and preclinical evaluation of radiolabeled alisertib (MLN8237)

JACM Goos, J Verbeek, AA Geldof, AC Hiemstra… - Nuclear medicine and …, 2016 - Elsevier
Introduction Survival of patients after resection of colorectal cancer liver metastasis
(CRCLM) is 36%–58%. Positron emission tomography (PET) tracers, imaging the …

[HTML][HTML] Liver background uptake of [18F] FLT in PET imaging

O Sergeeva, Y Zhang, J Kenyon… - American Journal of …, 2020 - ncbi.nlm.nih.gov
High liver uptake presents a problem for 3'-deoxy-3'-[18 F] fluorothymidine ([18 F] FLT) as a
radiotracer for imaging cellular proliferation in the liver with positron emission tomography …

Clinical translation of molecular imaging agents used in PET studies of cancer

LM Kenny, EO Aboagye - Advances in cancer research, 2014 - Elsevier
Over recent years, there has been a rapid expansion in our knowledge of the factors that
regulate tumor growth; this has resulted in the identification of new therapeutic targets and …

[HTML][HTML] Functional imaging biomarkers for assessing response to treatment in liver and lung metastases

L Bernardin, EAM O'Flynn, NM Desouza - Cancer Imaging, 2013 - ncbi.nlm.nih.gov
Management of patients with metastatic cancer and development of new treatments rely on
imaging to provide non-invasive biomarkers of tumour response and progression. The …