The fruit fly, Drosophila melanogaster, has been used to study genetics, development, and
signaling for nearly a century, but only over the past few decades has this tremendous …

Stem cells are characterized by their clonal ability both to generate differentiated progeny
and to undergo self‐renewal. Studies of adult mammalian organs have revealed stem cells …

Aging is associated with extensive remodeling of the heart, including basement membrane
(BM) components that surround cardiomyocytes. Remodeling is thought to impair cardiac …

Members of the T-Box gene family of transcription factors are important players in regulatory
circuits that generate myogenic and cardiogenic lineage diversities in vertebrates. We show …

In Drosophila, a population of muscle-committed stem-like cells called adult muscle
precursors (AMPs) keeps an undifferentiated and quiescent state during embryonic life. The …

Cytokinesis requires the coordination of cytoskeletal and plasma membrane dynamics. A
role for phosphatidylinositol lipids has been proposed for the successful completion of …

Genome-wide association studies have identified many susceptibility genes for adolescent
idiopathic scoliosis (AIS). However, most of the results are hard to be replicated in multi …

While combinatorial models of transcriptional regulation can be inferred for metazoan
systems from a priori biological knowledge, validation requires extensive and time …

Overexpression of Hairless (H) causes a remarkable degree of tissue loss and apoptosis
during imaginal development. H functions as antagonist in the Notch-signaling pathway in …

Mutations in SIX1 and in its co-factor, EYA1, underlie Branchiootorenal Spectrum disorder
(BOS), which is characterized by variable branchial arch, otic and kidney malformations …