Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome
characterized by impaired speech development and linguistic deficits. Recent genomic …

Most of our motor skills are not innately programmed, but are learned by a combination of
motor exploration and performance evaluation, suggesting that they proceed through a …

Sequential activation of neurons is a common feature of network activity during a variety of
behaviors, including working memory and decision making. Previous network models for …

Populations of neurons display an extraordinary diversity in the behaviors they affect and
display. Machine learning techniques have recently emerged that allow us to create …

In songbirds, the remarkable temporal precision of song is generated by a sparse sequence
of bursts in the premotor nucleus HVC. To distinguish between two possible classes of …

Significant trial-by-trial variation persists even in the most practiced skills. One prevalent
view is that such variation is simply 'noise'that the nervous system is unable to control or that …

Brain mechanisms for communication must establish a correspondence between sensory
and motor codes used to represent the signal. One idea is that this correspondence is …

Neural circuits are exquisitely organized, consisting of many different neuronal
subpopulations. However, it is difficult to assess the functional roles of these subpopulations …

The gene encoding the forkhead box transcription factor, FOXP2, is essential for developing
the full articulatory power of human language. Mutations of FOXP2 cause developmental …

While motor cortical circuits contain information related to specific movement parameters,
long-range inputs also have a critical role in action execution,. Thalamic projections can …