Dynamic contrast in scanning microscopic OCT

M Münter, M Vom Endt, M Pieper, M Casper… - Optics letters, 2020 - opg.optica.org
While optical coherence tomography (OCT) provides a resolution down to 1 µm, it has
difficulties in visualizing cellular structures due to a lack of scattering contrast. By evaluating …

Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast

M Münter, M Pieper, T Kohlfaerber… - Biomedical Optics …, 2021 - opg.optica.org
Volumetric imaging of dynamic processes with microscopic resolution holds a huge potential
in biomedical research and clinical diagnosis. Using supercontinuum light sources and high …

Computational approach for correcting defocus and suppressing speckle noise in line-field optical coherence tomography images

N Abbasi, K Chen, A Wong, K Bizheva - Biomedical Optics Express, 2024 - opg.optica.org
The trade-off between transverse resolution and depth-of-focus (DOF) typical for optical
coherence tomography (OCT) systems based on conventional optics, prevents “single-shot” …

Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography

H Schulz-Hildebrandt, M Pieper, C Stehmar… - Biomedical optics …, 2018 - opg.optica.org
Intravital microscopy (IVM) offers the opportunity to visualize static and dynamic changes of
tissue on a cellular level. It is a valuable tool in research and may considerably improve …

Dynamic micro-optical coherence tomography enables structural and metabolic imaging of the mammalian cochlea

H Schulz-Hildebrandt, S Spasic, F Hou… - Frontiers in Molecular …, 2024 - frontiersin.org
Sensorineural hearing loss (SNHL) is caused by damage to the mechanosensory hair cells
and auditory neurons of the cochlea. The development of imaging tools that can directly …

Intravital microscopic optical coherence tomography imaging to assess mucus-mobilizing interventions for muco-obstructive lung disease in mice

M Pieper, H Schulz-Hildebrandt… - … of Physiology-Lung …, 2020 - journals.physiology.org
Airway mucus obstruction is a hallmark of chronic lung diseases such as cystic fibrosis,
asthma, and COPD, and the development of more effective mucus-mobilizing therapies …

A Novel Network for Choroidal Segmentation Based on Enhanced Boundary Information

W Huang, C Qu, Y Yan - IEEE Access, 2025 - ieeexplore.ieee.org
Due to the inherent imaging characteristics of Optical Coherence Tomography (OCT), the
contrast between the choroid and sclera is low, presenting significant challenges in …

Method for in vivo assessment of cancer tissue inhomogeneity and accurate histology-like morphological segmentation based on Optical Coherence Elastography

AA Plekhanov, MA Sirotkina, AA Sovetsky… - bioRxiv, 2020 - biorxiv.org
We present a non-invasive method based on Optical Coherence Elastography (OCE)
enabling the in vivo segmentation of morphological tissue constituents, in particular …

Intravital imaging of mucus transport in asthmatic mice using microscopic optical coherence tomography

M Pieper, H Schulz-Hildebrandt… - … of Physiology-Lung …, 2022 - journals.physiology.org
Asthma is one of the most common chronic diseases. Mucus overproduction is consistently
linked to asthma morbidity and mortality. Despite the knowledge of the importance of mucus …

Fractal-based aberration-corrected full-field OCT

Y Zhu, Y Zhou, Z Guo - Biomedical Optics Express, 2023 - opg.optica.org
The Kolmogorov turbulence model has been validated as a quantitative 3D light scattering
model of the inhomogeneous refraction index of biological tissue using full-field OCT (FF …