[HTML][HTML] Current applications and different approaches for microbial L-asparaginase production

JJM Cachumba, FAF Antunes, GFD Peres… - Brazilian journal of …, 2016 - SciELO Brasil
ABSTRACT L-asparaginase (EC 3.5. 1.1) is an enzyme that catalysis mainly the asparagine
hydrolysis in L-aspartic acid and ammonium. This enzyme is presented in different …

A comprehensive review on microbial l‐asparaginase: Bioprocessing, characterization, and industrial applications

S Chand, RV Mahajan, JP Prasad… - Biotechnology and …, 2020 - Wiley Online Library
Abstract l‐Asparaginase (EC 3.5. 1.1.) is a vital enzyme that hydrolyzes l‐asparagine to l‐
aspartic acid and ammonia. This property of l‐asparaginase inhibits the protein synthesis in …

Characterization of L-asparaginase from marine-derived Aspergillus niger AKV-MKBU, its antiproliferative activity and bench scale production using industrial waste

AK Vala, B Sachaniya, D Dudhagara… - International journal of …, 2018 - Elsevier
Abstract L-asparaginase (LA), an enzyme with anticancer activities, produced by marine-
derived Aspergillus niger was subjected to purification and characterization. The purified …

[HTML][HTML] Optimization of production of anti-tumor l-asparaginase by free and immobilized marine Aspergillus terreus

AM Farag, SW Hassan, EA Beltagy… - The egyptian journal of …, 2015 - Elsevier
Abstract l-asparaginase plays a vital role in medical application, particularly in treatment of
acute lymphoblastic leukemia as an effective anti-tumor agent. In the present study, twenty …

Therapeutic enzymes: discoveries, production and applications

S Tandon, A Sharma, S Singh, S Sharma… - Journal of Drug Delivery …, 2021 - Elsevier
Enzymes today play a predominant role in the pharmaceutical industries due to their ability
to efficiently and selectively catalyze biochemical reactions in living systems. Since the …

[HTML][HTML] Thermostable Chitosan-L-Asparaginase conjugate from Aspergillus fumigatus is a novel structurally stable composite for abolishing acrylamide formation in …

MA Yassin, A Shindia, M Labib, M Soud, ASA El-Sayed - Lwt, 2022 - Elsevier
Abstract l-Asparaginase (Asnase) is one of the most promising approaches for acrylamide
mitigation in foods, however, the enzyme stability and catalytic efficiency are the major …

Cloning and expression of an anti-cancerous cytokine: human IL-29 gene in Chlamydomonas reinhardtii

M Akram, MA Khan, N Ahmed, R Bhatti, R Pervaiz… - AMB Express, 2023 - Springer
Green algae, Chlamydomonas reinhardtii, with low cultivation cost, absence of endotoxins
and insusceptibility to human pathogens is emerging as a potential system for the future …

[HTML][HTML] Fungal L-asparaginase: Strategies for production and food applications

MC da Cunha, JG dos Santos Aguilar… - Food research …, 2019 - Elsevier
L-asparaginase (L-asparagine amidohydrolase EC 3.5. 1.1) is of great importance in
pharmaceutical and food applications. This review aims to describe the production and use …

Sequencing and characterization of an L-asparaginase gene from a new species of Penicillium section Citrina isolated from Cerrado

KCR Andrade, RA Fernandes, DB Pinho… - Scientific reports, 2021 - nature.com
The enzyme L-asparaginase (L-ASNase) is used in the treatment of Acute Lymphoblastic
Leukemia. The preparations of this enzyme for clinical use are derived from bacterial …

[HTML][HTML] Purification, characterization and antiproliferative activity of L-asparaginase from Aspergillus oryzae CCT 3940 with no glutaminase activity

FFG Dias, ALTG Ruiz, A Della Torre, HH Sato - Asian Pacific Journal of …, 2016 - Elsevier
Objective To explore the anti-proliferative activity of purified l-asparaginase from Aspergillus
oryzae CCT 3940 (A. oryzae). Methods l-asparaginase was produced by submerged …