Despite the abundant ongoing research efforts, cancer remains one of the most challenging
diseases to treat globally. Due to the heterogenous nature of cancer, one of the major …

Liver progenitor cells (LPCs) are quiescent cells that are activated during liver injury and
thought to give rise to hepatocytes and cholangiocytes in order to support liver regeneration …

Liver zonation, the spatial separation of different metabolic pathways along the liver
sinusoids, is fundamental for proper functioning of this organ, and its disruption can lead to …

This textbook is designed to be a comprehensive assessment of current knowledge
regarding the surgical and general pathology of hepatobiliary tumors and tumor-like lesions …

The liver has an enormous potential to restore the parenchymal tissue loss due to injury.
This is accomplished by the proliferation of either the hepatocytes or liver progenitor cells in …

The efficacy of hepatocellular carcinoma (HCC) treatment is very low because of the high
percentage of recurrence and resistance to anticancer agents. Hepatic cancer stem cells …

Metastatic castrate-resistant prostate cancer (CRPC) remains uncurable and novel therapies
are needed to better treat patients. Aberrant Fibroblast Growth Factor Receptor (FGFR) …

Background Biliary atresia (BA) is a congenital, progressive, fibro-obliterative disease of the
extrahepatic biliary tree and the most common cause of end-stage liver disease in children …

Hepatocellular carcinoma (HCC) is the fastest-growing cause of cancer-related deaths
worldwide. Chronic inflammation and fibrosis are the greatest risk factors for the …

Purpose: p53 is mutated in about 50% of human cancers, mostly through missense
mutations. Expression of mutant p53 is associated with poor clinical outcomes or metastasis …