In addition to anti-tumor effects, ionizing radiation causes damage in normal tissues located
in the radiation portals. Oral complications of radiotherapy in the head and neck region are …

Radiation therapy for head and neck cancer causes significant secondary side-effects in
normal salivary glands, resulting in diminished quality of life for these individuals. Salivary …

Dry mouth must not be considered a trivial problem in the population, since it constitutes a
phenomenon with many aspects relative to oral function as well as quality of life. Up until …

This review presents data from the literature on oral adverse reactions from the perspectives
of subjective feelings of dry mouth (xerostomia) and objective measures of salivary gland …

The trp gene family has been proposed to encode the store-operated Ca 2+ influx (SOC)
channel (s). This study examines the role of Trp1 in the SOC mechanism of salivary gland …

Irradiation is a central treatment modality administered for head and neck malignancies. Its
major and most devastating side‐effect is an induced damage to the major salivary glands …

Salivary gland hypofunction causes significant morbidity and loss of quality of life for head
and neck cancer patients treated with radiotherapy. Preventing hypofunction is an unmet …

Treatment of most head and neck cancers includes radiotherapy. Salivary glands (SGs) in
the irradiation (IR) field are irreversibly damaged resulting in severe hyposalivation. We …

Neurotransmitter-regulation of fluid secretion in the salivary glands is achieved by a
coordinated sequence of intracellular signaling events, including the activation of membrane …

Radiation therapy for cancer of the head and neck can devastate the salivary glands and
partially devitalize the mandible and maxilla. As a result, saliva production is drastically …