High density lipoproteins and arteriosclerosis: role of cholesterol efflux and reverse cholesterol transport

A Von Eckardstein, JR Nofer… - … , thrombosis, and vascular …, 2001 - Am Heart Assoc
High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart
disease, and HDL exerts various potentially antiatherogenic properties, including the …

ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease

JF Oram, JW Heinecke - Physiological reviews, 2005 - journals.physiology.org
Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

Tangier disease and ABCA1

JF Oram - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2000 - Elsevier
Tangier disease is an autosomal recessive genetic disorder characterized by a severe high-
density lipoprotein (HDL) deficiency, sterol deposition in tissue macrophages, and prevalent …

ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins

JF Oram, AM Vaughan - Current opinion in lipidology, 2000 - journals.lww.com
Lipid-poor apolipoproteins remove cellular cholesterol and phospholipids by an active
transport pathway controlled by an ATP binding cassette transporter called ABCA1 (formerly …

Apolipoprotein E exhibits isoform‐specific promotion of lipid efflux from astrocytes and neurons in culture

M Michikawa, QW Fan, I Isobe… - Journal of …, 2000 - Wiley Online Library
Many studies have shown that apolipoprotein E (apoE) plays important roles in maintaining
intracellular lipid homeostasis in nonneuronal cells. However, little is known about the …

Apolipoprotein-mediated removal of cellular cholesterol and phospholipids

JF Oram, S Yokoyama - Journal of lipid research, 1996 - ASBMB
It is widely believed that high density lipoprotein (HDL) protects against cardiovascular
disease by removing excess cholesterol from cells of the artery wall. Recent cell culture …

Apolipoprotein A-II, HDL metabolism and atherosclerosis

A Tailleux, P Duriez, JC Fruchart, V Clavey - Atherosclerosis, 2002 - Elsevier
Apolipoprotein (Apo) AI and apo A-II are the major apolipoproteins of HDL. It is clearly
demonstrated that there are inverse relationships between HDL–cholesterol and apo AI …

HDL3-Mediated Inhibition of Thrombin-Induced Platelet Aggregation and Fibrinogen Binding Occurs via Decreased Production of Phosphoinositide-Derived Second …

JR Nofer, M Walter, B Kehrel, S Wierwille… - … , and vascular biology, 1998 - Am Heart Assoc
We demonstrate that physiological concentrations of HDL3 inhibit the thrombin-induced
platelet fibrinogen binding and aggregation in a time-and concentration-dependent fashion …

A novel action of Alzheimer's amyloid β-protein (Aβ): oligomeric Aβ promotes lipid release

M Michikawa, JS Gong, QW Fan… - Journal of …, 2001 - Soc Neuroscience
Interactions between amyloid β-protein (Aβ) and lipids have been suggested to play
important roles in the pathogenesis of Alzheimer's disease. However, the molecular …

Synthetic amphipathic helical peptides that mimic apolipoprotein AI in clearing cellular cholesterol.

AJ Mendez, GM Anantharamaiah… - The Journal of …, 1994 - Am Soc Clin Investig
Clearance of excess cholesterol from cells by HDL is facilitated by the interaction of HDL
apolipoproteins with cell-surface binding sites or receptors, a process that may be important …