Changes in the composition of the gut microbiota are associated with many human
diseases. So far, however, we have failed to define homeostasis or dysbiosis by the …

The communities of bacteria that reside in the intestinal tract are in constant competition
within this dynamic and densely colonized environment. At homeostasis, the equilibrium that …

Inflammatory diseases of the gastrointestinal tract are frequently associated with
dysbiosis,,,,,,,, characterized by changes in gut microbial communities that include an …

Bacteria can be engineered to function as diagnostics or therapeutics in the mammalian gut
but commercial translation of technologies to accomplish this has been hindered by the …

Changes in the microbial community structure are observed in individuals with intestinal
inflammatory disorders. These changes are often characterized by a depletion of obligate …

There is a groundswell of interest in using genetically engineered sensor bacteria to study
gut microbiota pathways, and diagnose or treat associated diseases. Here, we …

Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation
by using its virulence factors to invade the intestinal epithelium and survive in mucosal …

Conventional wisdom holds that microbes support their growth in vertebrate hosts by
exploiting a large variety of nutrients. We show here that use of a specific nutrient …

Genetic susceptibility, the mucosal immune system, and environmental factors such as the
microbiota, stress, and diet, contribute to the pathogenesis of inflammatory bowel disease …

Our intestine is host to a large microbial community (microbiota) that educates the immune
system and confers niche protection. Profiling of the gut‐associated microbial community …