Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen

A Maitra, T Munshi, J Healy, LT Martin… - FEMS microbiology …, 2019 - academic.oup.com
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …

Recent advances in understanding the antibacterial properties of flavonoids

TPT Cushnie, AJ Lamb - International journal of antimicrobial agents, 2011 - Elsevier
Antibiotic resistance is a major global problem and there is a pressing need to develop new
therapeutic agents. Flavonoids are a family of plant-derived compounds with potentially …

Bacterial cell wall assembly: still an attractive antibacterial target

TDH Bugg, D Braddick, CG Dowson, DI Roper - Trends in biotechnology, 2011 - cell.com
The development of new antibacterial agents to combat worsening antibiotic resistance is
still a priority area in anti-infectives research, but in the post-genomic era it has been more …

[HTML][HTML] Novel targets to develop new antibacterial agents and novel alternatives to antibacterial agents

TM Belete - Human Microbiome Journal, 2019 - Elsevier
Antibacterial agents have saved many lives and helped the growth of modern medicine over
the past half century. The emergence of drug resistance, jeopardizing the effectiveness of …

High-throughput screening of natural product and synthetic molecule libraries for antibacterial drug discovery

NJ Ayon - Metabolites, 2023 - mdpi.com
Due to the continued emergence of resistance and a lack of new and promising antibiotics,
bacterial infection has become a major public threat. High-throughput screening (HTS) …

Quinoline heterocyclic containing plant and marine candidates against drug-resistant Mycobacterium tuberculosis: A systematic drug-ability investigation

SS Swain, S Pati, T Hussain - European Journal of Medicinal Chemistry, 2022 - Elsevier
Today, tuberculosis (TB) caused by the acid-fast bacilli, Mycobacterium tuberculosis (Mtb) is
the most infectious killer disease globally with high morbidity and mortality rates. The rapid …

Natural products against key Mycobacterium tuberculosis enzymatic targets: Emerging opportunities for drug discovery

G Cazzaniga, M Mori, LR Chiarelli, A Gelain… - European journal of …, 2021 - Elsevier
For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …

Matching the power of high throughput screening to the chemical diversity of natural products

CJ Henrich, JA Beutler - Natural product reports, 2013 - pubs.rsc.org
Matching the power of high throughput screening to the chemical diversity of natural products -
Natural Product Reports (RSC Publishing) DOI:10.1039/C3NP70052F Royal Society of …

Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F

M Hrast, I Sosič, R Šink, S Gobec - Bioorganic chemistry, 2014 - Elsevier
The widespread emergence of resistant bacterial strains is becoming a serious threat to
public health. This thus signifies the need for the development of new antibacterial agents …

In vitro Anti-mycobacterial activity of selected medicinal plants against Mycobacterium tuberculosis and Mycobacterium bovis Strains

A Gemechu, M Giday, A Worku, G Ameni - BMC complementary and …, 2013 - Springer
Background Tuberculosis (TB) is a global burden with one–third of the world's population
infected with the pathogen Mycobacterium tuberculosis complex and annually 1.4 million …