Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

Resisting resistance: Acidic lipopeptide antibiotics are very effective in fighting multidrug‐
resistant Gram‐positive bacteria, including methicillin‐resistant Staphylococcus aureus and …

Calcium-dependent antibiotics (CDA) are cyclic lipopeptides assembled by nonribosomal
peptide synthetase (NRPS) enzymes. Active site modification of the 3-methyl glutamate …

Two novel cyclic hexapeptides containing both anthranilic acid and dehydroamino acid
units, sclerotides A (1) and B (2), were isolated from the marine-derived halotolerant …

Abstract α‐Amanitin and related amatoxins have been studied for more than six decades
mostly by isolation from death cap mushrooms. The total synthesis, however, remained …

α, β-Dehydroamino acids (ΔAAs) are nonproteinogenic residues that occur in both natural
and synthetic peptides. Their planar geometry at the α and β carbons profoundly impacts the …

The Vilsmeier–Haack reaction is a powerful tool to introduce formyl groups into electron-rich
arenes, but its wide application is significantly restricted by stoichiometric employment of …

A rare actinomycetal strain of the genus Actinomycetospora was found to produce a new
tryptophan derivative, designated mycetoindole (1). The structure of 1 was determined to be …

A convergent synthesis via the late-stage serine ligation of naturally occurring calcium-
dependent antibiotic CDA3a and its analogues has been developed, which allowed us to …

This review compiles the combined chemical and enzymatic synthesis of aromatic l-amino
acids (l-phenylalanine, l-tyrosine, l-DOPA, l-tryptophan, and their derivatives and precursors) …