Introduction: Sulfonamide compounds are significant class of synthetic bacteriostatic
antibiotics still which used today for the therapy of bacterial infections and those caused by …

Despite successful vaccination programs and effective treatments for some viral infections,
humans are still losing the battle with viruses. Persisting human pandemics, emerging and …

The natural phenomenon of drug resistance is a widespread issue that hampers the
performance of drugs in many major clinical indications. Antibacterial and antifungal drugs …

A novel phenoxy-bridged trinuclear nickel (II) complex [Ni3 (μ-L) 2 (bipy) 3](1)(where
H3L=(E)-2-hydroxy-N-(2-hydroxy-3, 5-diiodophenyl)-3, 5-diiodobenzohydrazonic acid, bipy …

The emergence and reemergence of multidrug‐resistant (MDR) bacteria and mycobacteria
in community and hospital periphery have directly enhanced the hospitalization costs …

Using the HIV-1 protease binding mode of MK-8718 and PL-100 as inspiration, a novel
aspartate binding bicyclic piperazine sulfonamide core was designed and synthesized. The …

Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses with a
genome that is 27–31 kbases in length. Critical genes include the spike (S), envelope (E) …

Leishmaniasis is considered a serious public health problem and the current available
therapy has several disadvantages, which makes the search for new therapeutic targets and …

A novel strategy for lead identification that we have dubbed the “Pocket-to-Lead” strategy is
demonstrated using HIV-1 protease as a model target. Sometimes, it is difficult to obtain hit …

Combination antiretroviral therapy (cART) is currently the most effective treatment for HIV-1
infection. HIV-1 protease inhibitors (PIs) are an important component of some regimens of …