Immunogenetics of juvenile idiopathic arthritis: A comprehensive review

AO Hersh, S Prahalad - Journal of autoimmunity, 2015 - Elsevier
Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthropathy of
childhood. Juvenile idiopathic arthritis is believed to be a complex genetic trait influenced by …

[HTML][HTML] Tumor necrosis factor alpha− 308 gene locus promoter polymorphism: an analysis of association with health and disease

MM Elahi, K Asotra, BM Matata, SS Mastana - Biochimica et Biophysica …, 2009 - Elsevier
Tumor necrosis factor-alpha (TNF-α) is a potent immunomediator and proinflammatory
cytokine that has been implicated in the pathogenesis of a large number of human diseases …

Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study

W de Jager, EPAH Hoppenreijs, NM Wulffraat… - Annals of the …, 2007 - ard.bmj.com
Background: Juvenile idiopathic arthritis (JIA) consists of a heterogeneous group of
disorders with, for the most part, an unknown immunopathogenesis. Although onset and …

TNF-α gene polymorphisms and expression

RR El-Tahan, AM Ghoneim, N El-Mashad - Springerplus, 2016 - Springer
Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine with an important role in
the pathogenesis of several diseases. Its encoding gene is located in the short arm of …

Oligoarticular and polyarticular JIA: epidemiology and pathogenesis

C Macaubas, K Nguyen, D Milojevic, JL Park… - Nature Reviews …, 2009 - nature.com
Juvenile idiopathic arthritis (JIA) refers to a group of chronic childhood arthropathies of
unknown etiology, currently classified into subtypes primarily on the basis of clinical …

Serum levels of interleukin‐10 and tumour necrosis factor‐α in chronic periodontitis

A Passoja, I Puijola, M Knuuttila… - Journal of clinical …, 2010 - Wiley Online Library
Passoja A, Puijola I, Knuuttila M, Niemelä O, Karttunen R, Raunio T, Tervonen T. Serum
levels of interleukin‐10 and tumour necrosis factor‐α in chronic periodontitis. J Clin …

Polymorphisms in the CD14 and IL‐6 genes associated with periodontal disease

T Tervonen, T Raunio, M Knuuttila… - Journal of clinical …, 2007 - Wiley Online Library
Aim: To compare the frequencies of cytokine and receptor molecule genotypes in patients
with chronic periodontitis with the corresponding frequencies in a reference population and …

Tumor necrosis factor–α is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population

S JimÊnez-Morales, R VelÂzquez-Cruz… - Human immunology, 2009 - Elsevier
There is a great deal of evidence that points to the association of the tumor necrosis factor-
alpha (TNF-α) gene as a common genetic factor in the pathogenesis of diseases that are …

Differential cytokine profiles in juvenile idiopathic arthritis subtypes revealed by cluster analysis

HJ van den Ham, W De Jager, JWJ Bijlsma… - …, 2009 - academic.oup.com
Objectives. With the introduction of high-throughput biomarker measurements, traditional
analysis of these markers is increasingly difficult. Using samples from a diverse group of …

The biology of TNF blockade

AG Suryaprasad, T Prindiville - Autoimmunity reviews, 2003 - Elsevier
Rheumatoid arthritis and Crohn's disease are costly diseases that result in significant long-
term patient disability. They are chronic inflammatory diseases that are associated with …