Comparative genomic analysis of the human gut microbiome reveals a broad distribution of metabolic pathways for the degradation of host-synthetized mucin glycans …
DA Ravcheev, I Thiele - Frontiers in genetics, 2017 - frontiersin.org
The colonic mucus layer is a dynamic and complex structure formed by secreted and
transmembrane mucins, which are high-molecular-weight and heavily glycosylated proteins …
transmembrane mucins, which are high-molecular-weight and heavily glycosylated proteins …
Neuraminidase A-exposed galactose promotes Streptococcus pneumoniae biofilm formation during colonization
KA Blanchette, AT Shenoy, J Milner… - Infection and …, 2016 - Am Soc Microbiol
Streptococcus pneumoniae is an opportunistic pathogen that colonizes the nasopharynx.
Herein we show that carbon availability is distinct between the nasopharynx and …
Herein we show that carbon availability is distinct between the nasopharynx and …
Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria
The human gut symbiont Ruminococcus gnavus scavenges host-derived N-
acetylneuraminic acid (Neu5Ac) from mucins by converting it to 2, 7-anhydro-Neu5Ac. We …
acetylneuraminic acid (Neu5Ac) from mucins by converting it to 2, 7-anhydro-Neu5Ac. We …
Streptococcus pneumoniae senses a human-like sialic acid profile via the response regulator CiaR
Streptococcus pneumoniae is a human-adapted pathogen that encounters terminally
sialylated glycoconjugates and free sialic acid (Sia) in the airways. Upon scavenging by the …
sialylated glycoconjugates and free sialic acid (Sia) in the airways. Upon scavenging by the …
Multiple evolutionary origins reflect the importance of sialic acid transporters in the colonization potential of bacterial pathogens and commensals
Located at the tip of cell surface glycoconjugates, sialic acids are at the forefront of host–
microbe interactions and, being easily liberated by sialidase enzymes, are used as …
microbe interactions and, being easily liberated by sialidase enzymes, are used as …
Neuraminidase B controls neuraminidase A-dependent mucus production and evasion
AJ Hammond, U Binsker, SD Aggarwal… - PLoS …, 2021 - journals.plos.org
Binding of Streptococcus pneumoniae (Spn) to nasal mucus leads to entrapment and
clearance via mucociliary activity during colonization. To identify Spn factors allowing for …
clearance via mucociliary activity during colonization. To identify Spn factors allowing for …
[HTML][HTML] Activation of a silent lactose utilization pathway in an evolved Listeria monocytogenes F2365 outbreak isolate
X Ma, NC Tapia, J Koomen, O van Mastrigt… - Food Research …, 2024 - Elsevier
Listeria monocytogenes, a widespread food-borne pathogen, utilizes diverse growth
substrates including mono-and di-saccharides via PEP-phosphotransferase (PTS) systems …
substrates including mono-and di-saccharides via PEP-phosphotransferase (PTS) systems …
Host-glycan metabolism is regulated by a species-conserved two-component system in Streptococcus pneumoniae
Pathogens of the Streptococcus genus inhabit many different environmental niches during
the course of an infection in a human host and the bacteria must adjust their metabolism …
the course of an infection in a human host and the bacteria must adjust their metabolism …
NanR, a Transcriptional Regulator That Binds to the Promoters of Genes Involved in Sialic Acid Metabolism in the Anaerobic Pathogen Clostridium perfringens
Among many other virulence factors, Clostridium perfringens produces three sialidases
NanH, NanI and NanJ. NanH lacks a secretion signal peptide and is predicted to be an …
NanH, NanI and NanJ. NanH lacks a secretion signal peptide and is predicted to be an …
Genome analysis of Mycoplasma synoviae strain MS-H, the most common M. synoviae strain with a worldwide distribution
Abstract Background The bacterial pathogen Mycoplasma synoviae can cause subclinical
respiratory disease, synovitis, airsacculitis and reproductive tract disease in poultry and is a …
respiratory disease, synovitis, airsacculitis and reproductive tract disease in poultry and is a …