Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
Tissue-specific macrophages: how they develop and choreograph tissue biology
Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
Physiology and diseases of tissue-resident macrophages
Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …
The semantics of microglia activation: neuroinflammation, homeostasis, and stress
Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …
every area of neuroscience. Initial reports focused on classical immune functions of …
Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS
TE Faust, G Gunner, DP Schafer - Nature Reviews Neuroscience, 2021 - nature.com
Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …
Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …
among the most frequent causes of disability and death worldwide. Current treatment …
Microglia regulation of synaptic plasticity and learning and memory
J Cornell, S Salinas, HY Huang… - Neural regeneration …, 2022 - journals.lww.com
Microglia are the resident macrophages of the central nervous system. Microglia possess
varied morphologies and functions. Under normal physiological conditions, microglia mainly …
varied morphologies and functions. Under normal physiological conditions, microglia mainly …
Oligodendrocyte precursor cells ingest axons in the mouse neocortex
Neurons in the developing brain undergo extensive structural refinement as nascent circuits
adopt their mature form. This physical transformation of neurons is facilitated by the …
adopt their mature form. This physical transformation of neurons is facilitated by the …
[HTML][HTML] Microglial remodeling of the extracellular matrix promotes synapse plasticity
Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we
define a molecular interaction between neurons and microglia that drives experience …
define a molecular interaction between neurons and microglia that drives experience …
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice
Microglia are brain-resident immune cells with a repertoire of functions in the brain.
However, the extent of their interactions with the vasculature and potential regulation of …
However, the extent of their interactions with the vasculature and potential regulation of …