In higher eukaryotes, most secretory and membrane proteins are synthesised by ribosomes
which are attached to the membrane of the rough endoplasmic reticulum (RER). This allows …

Using immunoprecipitation, we identified 13 patients with antibodies to the signal
recognition particle (SRP) from a collection of sera representing 265 poly‐myositis …

PROTEIN targeting to the endoplasmic reticulum in mammalian cells is catalysed by signal
recognition particle (SRP) 1, 2. Cross-linking experiments have shown that the subunit of …

334 SAIER ET AL. ally similar (see sections III and V). Cleavage of amino-terminal signal
sequences by signal peptidases occurs with similar specificities (89, 184, 220, 322); the …

The 54 kd protein subunit of the signal recognition particle (SRP54) has been shown to bind
signal sequences by UV crosslinking. Primary structure analysis and phylogenetic …

MOST proteins exported from mammalian cells contain a signal sequence which mediates
targeting to and insertion into the mem-brane of the endoplasmic reticulum (ER) 1, 2 …

Signal recognition particle (SRP), a small ribonucleoprotein required for targeting secretory
proteins to the ER, has three known functions: signal recognition, elongation arrest, and …

Signal recognition particle (SRP) plays the key role in targeting secretory proteins to the
membrane of the endoplasmic reticulum (Walter, P., and VR Lingappa. 1986. Annu. Rev …

The mammalian signal recognition particle (SRP) is a small cytoplasmic ribonucleoprotein
required for the cotranslational targeting of secretory proteins to the endoplasmic reticulum …

Tail-anchored (TA) proteins insert post-translationally into the membrane of the endoplasmic
reticulum (ER) and span the membrane by their C-terminal transmembrane domain. We …