Stereoselective Synthesis of Indolyl-C-glycosides Enabled by Sequential Aminopalladation and Heck Glycosylation of 2-Alkynylanilines with Glycals

X Xiao, P Han, JP Wan, J Liu - Organic Letters, 2023 - ACS Publications
An efficient and general approach for the synthesis of indolyl-C-glycosides via
aminopalladation and subsequent Heck-type glycosylation of easily available 2 …

Synthesis of C-glycosides enabled by palladium-catalyzed glycosylation reactions

W Tong, JP Wan, J Liu - Organic Chemistry Frontiers, 2024 - pubs.rsc.org
C-Glycosides represent a privileged class of carbohydrates, which exhibit remarkable
biological and pharmaceutical activities. Transition metal-catalyzed cross coupling reaction …

Recent Advances and Strategies towards Synthesis of Indolyl and Tryptophan‐C‐Glycoside Scaffolds

R Sangwan, Z Azeem… - Advanced Synthesis & …, 2024 - Wiley Online Library
Recently, C‐glycosidic bonds have emerged as pivotal elementary units present in many
naturally occurring alkaloids as well as in pharmaceutically active molecules. Because of the …

Cobalt's Dual Role in Promoting C3-Glycosylation of Indoles: Unraveling Mechanistic Insights

QQ Mu, AX Guo, X Cai, YY Qin, XL Liu, FZ Ye… - Organic …, 2023 - ACS Publications
In this study, we present a cobalt-catalyzed C3-glycosylation of indoles using
unfunctionalized glycals, yielding 3-indolyl-C-deoxyglycosides. These compounds hold …

Catalytic ring-strain release toward a facial and efficient synthesis of versatile C-glycosides

Y Zhang, XL Zhang, H Ding, Y Xu, XW Liu - Chinese Chemical Letters, 2024 - Elsevier
ABSTRACT C-Glycosides have been demonstrated to have distinct biological functions and
therefore display notable pharmacological values, whereas the access to the versatile …

A stereoselective organocatalyzed C-glycosylation of indole: implications of acceptor–catalyst–donor interactions

L Xie, W Liu, Z Guo, Q Jiao, X Shen, T Liu… - Organic Chemistry …, 2025 - pubs.rsc.org
A stereoselective pyridinium hexafluorophosphate-catalyzed C-glycosylation of indole is
presented, featuring the plausible formation of a catalyst–acceptor complex and a crucial H …

Triple Role of Proton Sponge (DMAN) in the Palladium-Catalyzed Direct Stereoselective Synthesis of C-Aryl Glycosides from Glycals

P Pradhan, S Moktan, A Biswas, A Das, R Lenka… - Organic …, 2024 - ACS Publications
The triple role of 1, 8-bis (dimethylamino) naphthalene (proton sponge) as a reductant,
ligand precursor, and organic base in the palladium-catalyzed Heck-type coupling reaction …

Efficient synthesis of indole-chalcones based glycohybrids and their anticancer activity

R Tyagi, K Yadav, A Khanna, SK Mishra… - Bioorganic & Medicinal …, 2024 - Elsevier
Indole based glycosides belong to the class of pharmacologically active molecules and
found in diverse natural compounds. Herein, we report synthesis of 1, 2, 3-triazole bridged …

Recent progress in the synthesis of natural product inspired bioactive glycohybrids

K Singh, S Sharma, R Tyagi, R Sagar - Carbohydrate Research, 2023 - Elsevier
Carbohydrates are a basic structural component that are indispensable to all cellular
processes. In addition to being employed as chiral starting materials in the synthesis of a …

Glycosyl esters as stable donors in chemical glycosylation

S Sanapala, S Pareek… - European Journal of …, 2025 - Wiley Online Library
Efficient glycosylation methods are continuously being developed to obtain homogeneously
pure carbohydrates to study their biological roles. The development of effective and …