[HTML][HTML] Intracellular Ca2+ sensing: its role in calcium homeostasis and signaling
R Bagur, G Hajnóczky - Molecular cell, 2017 - cell.com
Ca 2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can
become toxic and cause cell death. Selective control of specific targets depends on …
become toxic and cause cell death. Selective control of specific targets depends on …
Store-operated calcium channels
M Prakriya, RS Lewis - Physiological reviews, 2015 - journals.physiology.org
Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
virtually all metozoan cells and serve a wide variety of functions ranging from gene …
The SOAR of STIM1 interacts with plasma membrane lipids to form ER-PM contact sites
HA Cohen, E Zomot, T Nataniel, R Militsin, R Palty - Cell Reports, 2023 - cell.com
Depletion of Ca 2+ from the endoplasmic reticulum (ER) causes the ER Ca 2+ sensor STIM1
to form membrane contact sites (MCSs) with the plasma membrane (PM). At the ER-PM …
to form membrane contact sites (MCSs) with the plasma membrane (PM). At the ER-PM …
Intracellular Ca2+ Signalling in the Pathogenesis of Acute Pancreatitis: Recent Advances and Translational Perspectives
Intracellular Ca2+ signalling is a major signal transductional pathway in non-excitable cells,
responsible for the regulation of a variety of physiological functions. In the secretory …
responsible for the regulation of a variety of physiological functions. In the secretory …
Molecular mechanisms of STIM/Orai communication
Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels
triggers diverse signaling cascades that affect cellular processes like cell growth, gene …
triggers diverse signaling cascades that affect cellular processes like cell growth, gene …
Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating
The Orai1–STIM1 current undergoes slow Ca2+-dependent inactivation (SCDI) mediated by
the binding of SARAF to STIM1. Here we report the use of SCDI by SARAF as a probe of the …
the binding of SARAF to STIM1. Here we report the use of SCDI by SARAF as a probe of the …
Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1
L Maltan, S Weiß, H Najjar, M Leopold… - Nature …, 2023 - nature.com
Abstract Ca2+ release-activated Ca2+ (CRAC) channels, indispensable for the immune
system and various other human body functions, consist of two transmembrane (TM) …
system and various other human body functions, consist of two transmembrane (TM) …
TRPC Channels in the SOCE Scenario
Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels
that contribute to the modulation of a number of physiological functions in a variety of cell …
that contribute to the modulation of a number of physiological functions in a variety of cell …
Activation mechanisms and structural dynamics of STIM proteins
M Sallinger, H Grabmayr, C Humer… - The Journal of …, 2024 - Wiley Online Library
The family of stromal interaction molecules (STIM) includes two widely expressed single‐
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …
Anoctamin 8 tethers endoplasmic reticulum and plasma membrane for assembly of Ca2+ signaling complexes at the ER/PM compartment
Communication and material transfer between membranes and organelles take place at
membrane contact sites (MCSs). MCSs between the ER and PM, the ER/PM junctions, are …
membrane contact sites (MCSs). MCSs between the ER and PM, the ER/PM junctions, are …