Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …

Mild acidification caused by transcutaneous administration of carbon dioxide (CO2) has
been reported to improve some epidermal skin impairments, such as desquamation and …

Sustained tissue hypoxia is associated with many pathophysiological conditions, including
chronic inflammation, chronic wounds, slow-healing fractures, microvascular complications …

Chronic wounds in diabetics are difficult to treat, therefore, adjuvant therapies have been
investigated. Bathing in CO2‐rich water (spa therapy) has been known in Europe for …

Introduction Microvascular function is impaired in patients with diabetes mellitus (DM) and is
involved in numerous DM complications. Several microvascular-supporting interventions …

The status of peripheral arteries is known to be a key physiological indicator of the body's
response to both acute and chronic medical conditions. In this paper, peripheral artery …

The treatment of patients with complex regional pain syndrome (CRPS) takes place in an
interdisciplinary and multimodal setting. Physical therapies represent a major treatment …

Seit dem 19. Jahrhundert werden Kohlensäurebäder als natürliche Quellen zu
therapeutischen Zwecken in Europa angewendet 1. Durch die artifizielle Herstellung von …

Aim: Diabetic symmetrical peripheral neuropathy is a common complication of diabetes
mellitus. Patients treated with transcutaneous CO2 application for chronic wounds reported …

Background. To identify potential opportunities for carboxytherapy, it is necessary to assess
the importance of various signaling mechanisms of sensitivity to СО2 and summarize the …