Covering: 2002. Previous review: Nat. Prod. Rep., 2003, 20, 1 This review covers the literature published in 2002 for marine natural products, with 579 citations (413 for the …
Aquatic invertebrates are a major source of biomaterials and bioactive natural products that can find applications as pharmaceutics, nutraceutics, cosmetics, antibiotics, antifouling …
The microtubule (MT) associated protein tau, which is highly expressed in the axons of neurons, is an endogenous MT-stabilizing agent that plays an important role in axonal …
Covering: late 2008 to August 2013 Nature has yielded numerous classes of chemically distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel …
LL Hong, YF Ding, W Zhang, HW Lin - Marine Life Science & Technology, 2022 - Springer
Marine sponges are productive sources of bioactive secondary metabolites with over 200 new compounds isolated each year, contributing 23% of approved marine drugs so far. This …
QX Yue, X Liu, DA Guo - Planta medica, 2010 - thieme-connect.com
Natural products, especially microtubule-binding natural products, play important roles in the war against cancer. From the clinical use of vinblastine in 1961, paclitaxel in 1992, to …
A Lumbroso, N Abermil, B Breit - Chemical Science, 2012 - pubs.rsc.org
Atom economic macrolactonization and lactonization via redox-neutral rhodium-catalyzed coupling of terminal alkynes with carboxylic acids - Chemical Science (RSC Publishing) DOI:10.1039/C2SC00812B …
S Dall'Acqua - Current topics in medicinal chemistry, 2014 - ingentaconnect.com
Natural products still play an important role in the medicinal chemistry, especially in some therapeutic areas. As example more than 60% of currently-used anticancer agents are …
The sponge is one of the oldest multicellular invertebrates in the world. Marine sponges represent one of the extant metazoans of 700–800 million years. They are classified in four …