Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Alzheimer′ s disease (AD) is the most common type of dementia. In connection with the
global trend of prolonging human life and the increasing number of elderly in the population …

Abstract DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers
altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA …

The human tau protein is implicated in a wide range of neurodegenerative “tauopathy”
diseases, consisting of Alzheimer's disease (AD) and frontotemporal lobar degeneration …

Tauopathies are degenerative diseases characterized by the accumulation of
phosphorylated tau in neurons and glial cells. With some exceptions, tau deposits in …

Tau is a microtubule-associated protein responsible mainly for stabilizing the neuronal
microtubule network in the brain. Under normal conditions, tau is highly soluble and adopts …

The hyperphosphorylated microtubule-associated protein tau is present in several
neurodegenerative diseases, although the causal relationship remains elusive. Few mouse …

The accumulation of hyperphosphorylated fibrillar Tau aggregates in the brain is one of the
defining hallmarks of Tauopathy diseases, including Alzheimer's disease. However, the …

Aims The present study analyses molecular characteristics of the locus coeruleus (LC) and
projections to the amygdala and hippocampus at asymptomatic early and middle Braak …

Tau pathogenicity in Alzheimer9s disease and other tauopathies is thought to involve the
generation of hyperphosphorylated, truncated, and oligomeric tau species with enhanced …