Complex IV–the regulatory center of mitochondrial oxidative phosphorylation
B Kadenbach - Mitochondrion, 2021 - Elsevier
ATP, the universal energy currency in all living cells, is mainly synthesized in mitochondria
by oxidative phosphorylation (OXPHOS). The final and rate limiting step of the respiratory …
by oxidative phosphorylation (OXPHOS). The final and rate limiting step of the respiratory …
Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
Mitochondrial ClpP is a serine protease located in the mitochondrial matrix. This protease
participates in mitochondrial protein quality control by degrading misfolded or damaged …
participates in mitochondrial protein quality control by degrading misfolded or damaged …
Mitochondrial protein import dysfunction: mitochondrial disease, neurodegenerative disease and cancer
The majority of proteins localised to mitochondria are encoded by the nuclear genome, with
approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this …
approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this …
Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery
Most mitochondrial proteins are translated in the cytosol and imported into mitochondria.
Mutations in the mitochondrial protein import machinery cause human pathologies …
Mutations in the mitochondrial protein import machinery cause human pathologies …
Emerging role of mitochondrial DNA as a major driver of inflammation and disease progression
Inflammation benefits the host by promoting the elimination of invading pathogens and
clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and …
clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and …
Dissecting the roles of mitochondrial complex I intermediate assembly complex factors in the biogenesis of complex I
Mitochondrial complex I harbors 7 mitochondrial and 38 nuclear-encoded subunits. Its
biogenesis requires the assembly and integration of distinct intermediate modules, mediated …
biogenesis requires the assembly and integration of distinct intermediate modules, mediated …
Mitochondrial morphofunction in mammalian cells
EP Bulthuis, MJW Adjobo-Hermans… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: In addition to their classical role in cellular ATP production, mitochondria are of
key relevance in various (patho) physiological mechanisms including second messenger …
key relevance in various (patho) physiological mechanisms including second messenger …
Lycorine promotes IDH1 acetylation to induce mitochondrial dynamics imbalance in colorectal cancer cells
FF Zhuo, L Li, TT Liu, XM Liang, Z Yang, YZ Zheng… - Cancer Letters, 2023 - Elsevier
Abstract Isocitrate dehydrogenase (IDH) 1 and 2, as essential enzymes in energy
metabolism, contribute to the survival and drug resistance of a variety of solid tumors …
metabolism, contribute to the survival and drug resistance of a variety of solid tumors …
Cryo-EM structure of the human mitochondrial translocase TIM22 complex
Dear Editor, Mitochondria are essential organelles in cellular metabolism, homeostasis, and
apoptosis. 1, 2 Most mitochondrial proteins are synthesized as precursors in the cytosol and …
apoptosis. 1, 2 Most mitochondrial proteins are synthesized as precursors in the cytosol and …
Mitochondrial biology and dysfunction in secondary mitochondrial disease
Mitochondrial diseases are a broad, genetically heterogeneous class of metabolic disorders
characterized by deficits in oxidative phosphorylation (OXPHOS). Primary mitochondrial …
characterized by deficits in oxidative phosphorylation (OXPHOS). Primary mitochondrial …