Therapeutic benefits of rutin and its nanoformulations

R Negahdari, S Bohlouli, S Sharifi… - Phytotherapy …, 2021 - Wiley Online Library
Background Rutin as a natural flavonoid compound has revealed an extensive range of
therapeutic potentials. Purpose The current paper is focused on the numerous studies on …

Health benefits and limitations of rutin-A natural flavonoid with high nutraceutical value

R Semwal, SK Joshi, RB Semwal, DK Semwal - Phytochemistry Letters, 2021 - Elsevier
Rutin, a plant-derived natural flavonoid, is considered among the top therapeutically active
phytochemicals and one of the major bioactive constituents of a variety of natural foods and …

Flavonoids regulate tumor-associated macrophages–from structure-activity relationship to clinical potential

Q Sun, Q Liu, X Zhou, X Wang, H Li, W Zhang… - Pharmacological …, 2022 - Elsevier
In recent years, the strategy for tumor therapy has changed from focusing on the direct killing
effect of different types of therapeutic agents on cancer cells to the new mainstream of multi …

A flavonoid on the brain: quercetin as a potential therapeutic agent in central nervous system disorders

D Wróbel-Biedrawa, K Grabowska, A Galanty… - Life, 2022 - mdpi.com
Quercetin is one of the most common, naturally occurring flavonoids, structurally classified to
the flavonol subfamily. This compound, found in many edible and medicinal plants either as …

Comprehensive and critical view on the anti-inflammatory and immunomodulatory role of natural phenolic antioxidants

AM Pisoschi, F Iordache, L Stanca, C Cimpeanu… - European Journal of …, 2024 - Elsevier
The immune response encompasses innate and adaptive immunity, each with distinct and
specific activities. The innate immune system is constituted by phagocytic cells …

Anticancer activity of rutin and its combination with ionic liquids on renal cells

R Caparica, A Júlio, MEM Araújo, AR Baby, P Fonte… - Biomolecules, 2020 - mdpi.com
The renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel
and more effective therapies, while minimizing toxicity, continues to be fundamental in …

Quercetin: a promising phytochemical for the treatment of glioblastoma multiforme

E Tavana, H Mollazadeh, E Mohtashami… - …, 2020 - Wiley Online Library
Quercetin, a plant‐derived flavonoid, is known for its antitumor and antiproliferative activities.
Glioblastoma multiforme (GBM), as a highly aggressive cerebrum tumor, has a poor …

Flavonoids synergistically enhance the anti-glioblastoma effects of chemotherapeutic drugs

K Zhai, A Mazurakova, L Koklesova, P Kubatka… - Biomolecules, 2021 - mdpi.com
Flavonoids are polyphenolic plant secondary metabolites with pleiotropic biological
properties, including anti-cancer activities. These natural compounds have potential utility in …

Anticancer mechanism of flavonoids on high-grade adult-type diffuse gliomas

SC Wong, MNA Kamarudin, R Naidu - Nutrients, 2023 - mdpi.com
High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult
tumors of the central nervous system. Despite the advancements in the multimodality …

Prediction of cell migration potential on human breast cancer cells treated with Albizia lebbeck ethanolic extract using extreme machine learning

H Umar, MR Aliyu, AG Usman, UM Ghali, SI Abba… - Scientific Reports, 2023 - nature.com
Cancer is one of the major causes of death in the modern world, and the incidence varies
considerably based on race, ethnicity, and region. Novel cancer treatments, such as surgery …