Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Proteomics involves the applications of technologies for the identification and quantification
of overall proteins present content of a cell, tissue or an organism. It supplements the other …

β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …

Nuclear magnetic resonance (NMR) is widely used across many fields of science because
of the rich data it produces, and some of the most valuable data come from studies of …

Detergents are invaluable tools for studying membrane proteins. However, these
deceptively simple, amphipathic molecules exhibit complex behavior when they self …

The native environment of membrane proteins is complex and scientists have felt the need
to simplify it to reduce the number of varying parameters. However, experimental problems …

Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a
model for fungal pathogenesis, and an opportunistic human pathogen of global importance …

The β-barrel membrane protein is found in the outer membranes of bacteria, mitochondria
and chloroplasts. Approximately 2–3% of the genes in Gram-negative bacterial genomes …

Enzyme catalysis is an inherently dynamic process. Binding and release of ligands is often
accompanied by conformational changes, both subtle and dramatic (reviewed more …

The OmpA outer membrane protein of Escherichia coli and other enterobacteria is a
multifaceted protein. This protein is expressed to very high levels and ompA is tightly …