Preserving the integrity of the DNA double helix is crucial for the maintenance of genomic
stability. Therefore, DNA double‐strand breaks represent a serious threat to cells. In this …

Cornelia de Lange syndrome (CdLS; MIM# 122470, 300590, 610759, 614701, 300882) is a
rare and clinically variable disorder that affects multiple organs. It is characterized by …

Much of the HSV-1 life cycle is carried out in the cell nucleus, including the expression,
replication, repair, and packaging of viral genomes. Viral proteins, as well as cellular factors …

Disruptions in ribosomal biogenesis would be expected to have global and in fact lethal
effects on a developing organism. However, mutations in ribosomal protein genes have …

Characteristic or classic phenotype of Cornelia de Lange syndrome (CdLS) is associated
with a recognisable facial pattern. However, the heterogeneity in causal genes and the …

Background & aims Studies suggest that fasting before or during chemotherapy may induce
differential stress resistance, reducing the adverse effects of chemotherapy and enhancing …

Cognitive disorders (CDs) are a heterogeneous group of disorders for which the genetic
foundations are rapidly being uncovered. The large number of CD-associated gene …

In recent years, many genes have been associated with chromatinopathies classified as
“Cornelia de Lange Syndrome‐like.” It is known that the phenotype of these patients …

Preservation and development of life depend on the adequate segregation of sister
chromatids during mitosis and meiosis. This process is ensured by the cohesin multi-subunit …

The coordinated tissue-specific regulation of gene expression is essential for the proper
development of all organisms. Mutations in multiple transcriptional regulators cause a group …