Platelets, generated from precursor megakaryocytes (MKs), are central mediators of
hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated …

Background and Aims Besides the crucial role in the treatment of acute ischemic stroke
(AIS), mechanical thrombectomy represents a unique opportunity for researchers to study …

Extracellular protein disulfide isomerases (PDIs), including PDI, endoplasmic reticulum
protein 57 (ERp57), ERp72, ERp46, and ERp5, are required for in vivo thrombus formation …

Blast injuries include the various types of internal and external trauma caused by the impact
force of high-speed blast waves with multiple mechanisms involved. Thoracic blast exposure …

Background Chemotherapy-induced thrombocytopenia (CIT) is a severe adverse drug
reaction, and the main reason for CIT is the destruction of megakaryocytes (MKs, precursor …

Abstract Ormeloxifene (ORM)(3, 4‐trans‐2, 2‐dimethyl‐3‐phenyl‐4‐p‐(β‐pyrrolidinoethoxy)
phenyl‐7‐methoxychroman), world's first nonsteroidal selective estrogen receptor modulator …

Mitochondria and the endoplasmic reticulum (ER) are known to promote cardiac
ischemia/reperfusion (I/R) injury. Overexpression of yes-associated protein (YAP) and/or …

Acute erythroid leukemia (AEL) is a rare and aggressive hematologic malignancy with no
specific treatment. Sanguisorba officinalis L.(S. officinalis), a well-known traditional Chinese …

Platelets are derived from megakaryocytes and play an important role in blood coagulation.
By using high throughput sequencing, we have found that the long non-coding RNA …

Primary immune thrombocytopenia (ITP) is linked to specific pathogenic mechanisms, yet its
relationship with mitophagy and ferroptosis is poorly understood. This study aimed to identify …