Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Bond-selective imaging by optically sensing the mid-infrared photothermal effect

Y Bai, J Yin, JX Cheng - Science advances, 2021 - science.org
Mid-infrared (IR) spectroscopic imaging using inherent vibrational contrast has been broadly
used as a powerful analytical tool for sample identification and characterization. However …

[HTML][HTML] Label-free mid-infrared photothermal live-cell imaging beyond video rate

G Ishigane, K Toda, M Tamamitsu, H Shimada… - Light: Science & …, 2023 - nature.com
Advancement in mid-infrared (MIR) technology has led to promising biomedical applications
of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR …

Mid-infrared photothermal microscopy: principle, instrumentation, and applications

Q Xia, J Yin, Z Guo, JX Cheng - The Journal of Physical Chemistry …, 2022 - ACS Publications
Midinfrared photothermal (MIP) microscopy, also called optical photothermal infrared (O-
PTIR) microscopy, is an emerging tool for bond-selective chemical imaging of living …

Super-resolution imaging of non-fluorescent molecules by photothermal relaxation localization microscopy

P Fu, W Cao, T Chen, X Huang, T Le, S Zhu… - Nature …, 2023 - nature.com
Optical imaging beyond the diffraction limit has led to tremendous breakthroughs in recent
years. Compared with widely employed fluorescence-based approaches, label-free imaging …

Video-rate mid-infrared photothermal imaging by single-pulse photothermal detection per pixel

J Yin, M Zhang, Y Tan, Z Guo, H He, L Lan… - Science …, 2023 - science.org
By optically sensing absorption-induced photothermal effect, mid-infrared (IR) photothermal
(MIP) microscope enables super-resolution IR imaging of biological systems in water …

[HTML][HTML] Digital histopathology by infrared spectroscopic imaging

R Bhargava - Annual Review of Analytical Chemistry, 2023 - annualreviews.org
Infrared (IR) spectroscopic imaging records spatially resolved molecular vibrational spectra,
enabling a comprehensive measurement of the chemical makeup and heterogeneity of …

Roadmap on Label‐Free Super‐Resolution Imaging

VN Astratov, YB Sahel, YC Eldar… - Laser & Photonics …, 2023 - Wiley Online Library
Label‐free super‐resolution (LFSR) imaging relies on light‐scattering processes in
nanoscale objects without a need for fluorescent (FL) staining required in super‐resolved FL …

[PDF][PDF] Improved spatiotemporal resolution of anti-scattering super-resolution label-free microscopy via synthetic wave 3D metalens imaging

Y Xiao, L Chen, M Pu, M Xu, Q Zhang, Y Guo… - Opto-Electronic …, 2023 - researching.cn
Super-resolution (SR) microscopy has dramatically enhanced our understanding of
biological processes. However, scattering media in thick specimens severely limits the …

Fluorescence-detected mid-infrared photothermal microscopy

Y Zhang, H Zong, C Zong, Y Tan, M Zhang… - Journal of the …, 2021 - ACS Publications
Mid-infrared photothermal microscopy is a new chemical imaging technology in which a
visible beam senses the photothermal effect induced by a pulsed infrared laser. This …