Background Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-
localised protein and member of the leucine zipper family of transcription factors. Best …

Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

Calcium-independent phospholipase A 2 γ (iPLA 2 γ)/patatin-like phospholipase domain-
containing lipase 8 (PNPLA8) is one of the iPLA 2 enzymes, which do not require Ca 2+ ion …

Fluvastatin (FLV) is a statin family member that may play a role in modulating a variety of
medical disorders such as atherosclerosis and breast cancer. The present study addresses …

Patients with metastatic or relapsed/refractory osteosarcoma (OS) have a 5-year survival
rate of< 30%. This has remained unchanged over several decades. One of the factors …

Although cancer cells use heparanase for tumor metastasis, favourable effects of
heparanase have been reported in the management of Alzheimer's disease and diabetes …

Glomerular visceral epithelial cells (podocytes) play a critical role in the maintenance of
glomerular permselectivity. Podocyte injury, manifesting as proteinuria, is the cause of many …

Calcium-independent phospholipase A2γ (iPLA2γ) is localized in glomerular epithelial cells
(GECs)/podocytes at the mitochondria and endoplasmic reticulum, and can mediate release …

Broiler ascites syndrome (AS) is one of the main diseases threatening the health of broilers.
It is well documented that myocardial hypertrophy and failure is one of the key mechanisms …

Ste20-like kinase SLK is critical for embryonic development and may play an important role
in wound healing, muscle homeostasis, cell migration, and tumor growth. Mice with …