Protein design: From the aspect of water solubility and stability

R Qing, S Hao, E Smorodina, D Jin, A Zalevsky… - Chemical …, 2022 - ACS Publications
Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Coiled‐coils: The long and short of it

L Truebestein, TA Leonard - Bioessays, 2016 - Wiley Online Library
Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains
of some proteins are almost invariant in sequence and length, betraying a structural and …

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

S Pankiv, EA Alemu, A Brech, JA Bruun… - Journal of Cell …, 2010 - rupress.org
Autophagy is the main eukaryotic degradation pathway for long-lived proteins, protein
aggregates, and cytosolic organelles. Although the protein machinery involved in the …

Personalized immunotherapy against several neuronal and brain tumors

S Kuttruff-coqui, T Weinschenk, J Fritsche… - US Patent …, 2021 - Google Patents
2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Structural specificity in coiled-coil interactions

G Grigoryan, AE Keating - Current opinion in structural biology, 2008 - Elsevier
Coiled coils have a rich history in the field of protein design and engineering. Novel
structures, such as the first seven-helix coiled coil, continue to provide surprises and …

tRNA synthetase: tRNA aminoacylation and beyond

YLJ Pang, K Poruri, SA Martinis - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The aminoacyl‐tRNA synthetases are prominently known for their classic function in the first
step of protein synthesis, where they bear the responsibility of setting the genetic code. Each …

Rab7: role of its protein interaction cascades in endo-lysosomal traffic

T Wang, Z Ming, W Xiaochun, W Hong - Cellular signalling, 2011 - Elsevier
Protein–protein interaction cascades are crucial for cellular signaling pathways and cell
morphogenesis. Membrane traffic along the secretory and endocytic pathways is similarly …

Stepwise evolution of the centriole-assembly pathway

Z Carvalho-Santos, P Machado… - Journal of cell …, 2010 - journals.biologists.com
The centriole and basal body (CBB) structure nucleates cilia and flagella, and is an essential
component of the centrosome, underlying eukaryotic microtubule-based motility, cell division …

Coiled-coil domain-containing (CCDC) proteins: functional roles in general and male reproductive physiology

PP Priyanka, S Yenugu - Reproductive Sciences, 2021 - Springer
The coiled-coil domain-containing (CCDC) proteins have been implicated in a variety of
physiological and pathological processes. Their functional roles vary from their interaction …

[HTML][HTML] Functional expansion of human tRNA synthetases achieved by structural inventions

M Guo, P Schimmel, XL Yang - FEBS letters, 2010 - Elsevier
Known as an essential component of the translational apparatus, the aminoacyl-tRNA
synthetase family catalyzes the first step reaction in protein synthesis, that is, to specifically …