Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely
related to focal adhesion kinase (FAK), which plays an important role in sensing cell …

Spontaneous thought is an adaptive cognitive process that can produce novel and insightful
thought sequences useful in guiding future behavior. In many psychiatric disorders …

In a constantly changing environment, organisms must track the current relationship
between actions and their specific consequences and use this information to guide decision …

Cocaine self-administration can disrupt the capacity of humans and rodents to flexibly
modify familiar behavioral routines, even when they become maladaptive or unbeneficial …

Huntington disease (HD) is a devastating disease due to autosomal dominant mutation in
the HTT gene. Its pathophysiology involves multiple molecular alterations including …

In day-to-day life, we often choose between pursuing familiar behaviors that have been
rewarded in the past or adjusting behaviors when new strategies might be more fruitful. The …

The health and economic costs associated with substance use disorders (SUDs) are
immense, with a rise in overdose deaths related to stimulant or stimulant and opiate use …

La maladie d'Alzheimer (MA) est une maladie neurodégénérative et la forme la plus
fréquente de démence. Elle se caractérise neuropathologiquement par une accumulation …

In day-to-day life, we often choose between pursuing familiar behaviors that have been
rewarded in the past or adjusting behaviors when new strategies might be more fruitful. The …