Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …

Abstract Long interspersed element 1 (LINE-1) is the only protein-coding transposon that is
active in humans. LINE-1 propagates in the genome using RNA intermediates via …

Constitutive heterochromatin is responsible for genome repression of DNA enriched in
repetitive sequences, telomeres, and centromeres. During physiological and pathological …

Retrotransposons are genomic DNA sequences that copy themselves to new genomic
locations via RNA intermediates; LINE-1 is the only active and autonomous retrotransposon …

Improved biomarkers are needed for early cancer detection, risk stratification, treatment
selection, and monitoring treatment response. Although proteins can be useful blood-based …

Long interspersed nuclear element-1 (LINE-1) retrotransposition is a major hallmark of
cancer accompanied by global chromosomal instability, genomic instability, and genetic …

Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA
into cytoplasmic Alu complementary DNA (cDNA) has been implicated in retinal pigmented …

Abstract Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p)
expression is a common feature of many cancer types, including high-grade serous ovarian …

Nearly half of the human genome is made of transposable elements (TEs) whose activity
continues to impact its structure and function. Among them, Long INterspersed Element …

Neoantigen-based immunotherapy has yielded promising results in clinical trials. However,
it is limited to tumor-specific mutations, and is often tailored to individual patients. Identifying …