Intracerebral hemorrhage (ICH) is the second most common type of stroke and has one of
the highest fatality rates of any disease. There are many clinical signs and symptoms after …

As stroke care has developed, there has been a need to robustly assess the efficacy of
interventions both at the level of the individual stroke survivor and in the context of clinical …

Human diseases may be modeled in animals to allow preclinical assessment of putative
new clinical interventions. Recent, highly publicized failures of large clinical trials called into …

Despite successful clot retrieval in large vessel occlusion stroke,∼ 50% of patients have an
unfavorable clinical outcome. The mechanisms underlying this functional reperfusion failure …

Microglia continuously survey the brain parenchyma and actively shift status following
stimulation. These processes demand a unique bioenergetic programme; however, little is …

Ischemic stroke is an acute and severe neurological disease, resulting in disability and
death. Reperfusion to an ischemic brain is a means to reverse brain damage after stroke; …

Cytosolic double‐stranded DNA (dsDNA) is a danger signal that is tightly monitored and
sensed by nucleic acid‐sensing pattern recognition receptors. We study the inflammatory …

Microglia are the main immune cells in the brain and have roles in brain homeostasis and
neurological diseases. Mechanisms underlying microglia–neuron communication remain …

Over 700 drugs have failed in stroke clinical trials, an unprecedented rate thought to be
attributed in part to limited and isolated testing often solely in “young” rodent models and …

Stroke is a common disease with high mortality worldwide. The endogenous neural
regeneration during the intracerebral hemorrhage (ICH) stroke is restricted by the brain …