T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …

T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune
responses to mediate inflammation and regulate other types of immune cells. Work in the …

The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …

Chimeric antigen receptor (CAR) T cell therapy has limited efficacy against solid tumors, and
one major challenge is T cell exhaustion. To address this challenge, we performed a …

During chronic stimulation, CD8+ T cells acquire an exhausted phenotype characterized by
expression of inhibitory receptors, down-modulation of effector function, and metabolic …

Regulatory T (Treg) cells suppress effective antitumor immunity in tumor-bearing hosts,
thereby becoming promising targets in cancer immunotherapy. Despite the importance of …

Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major
revision of the TH subset paradigm and substantial progress has been made in deciphering …

Th17 cells play an important role in the abnormal immune response in inflammatory bowel
disease (IBD) and are involved in the development and progression of inflammation and …

It has been shown that innate immune responses can adopt adaptive properties such as
memory. Whether T cells utilize innate immune signaling pathways to diversify their …