Congenital diaphragmatic hernia: current management strategies from antenatal diagnosis to long-term follow-up
E Kirby, R Keijzer - Pediatric Surgery International, 2020 - Springer
Congenital diaphragmatic hernia (CDH) is a developmental birth defect consisting of a
diaphragmatic defect and abnormal lung development. CDH complicates 2.3–2.8 per …
diaphragmatic defect and abnormal lung development. CDH complicates 2.3–2.8 per …
Cell-Free Amniotic Fluid and Regenerative Medicine: Current Applications and Future Opportunities
Amniotic fluid (AF) provides critical biological and physical support for the developing fetus.
While AF is an excellent source of progenitor cells with regenerative properties, recent …
While AF is an excellent source of progenitor cells with regenerative properties, recent …
Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents
L Antounians, VD Catania, L Montalva, BD Liu… - Science Translational …, 2021 - science.org
Fetal lung underdevelopment, also known as pulmonary hypoplasia, is characterized by
decreased lung growth and maturation. The most common birth defect found in babies with …
decreased lung growth and maturation. The most common birth defect found in babies with …
Fetal hypoplastic lungs have multilineage inflammation that is reversed by amniotic fluid stem cell extracellular vesicle treatment
Antenatal administration of extracellular vesicles from amniotic fluid stem cells (AFSC-EVs)
reverses features of pulmonary hypoplasia in models of congenital diaphragmatic hernia …
reverses features of pulmonary hypoplasia in models of congenital diaphragmatic hernia …
The regenerative potential of amniotic fluid stem cell extracellular vesicles: lessons learned by comparing different isolation techniques
L Antounians, A Tzanetakis, O Pellerito, VD Catania… - Scientific reports, 2019 - nature.com
Extracellular vesicles (EVs) derived from amniotic fluid stem cells (AFSCs) mediate anti-
apoptotic, pro-angiogenic, and immune-modulatory effects in multiple disease models, such …
apoptotic, pro-angiogenic, and immune-modulatory effects in multiple disease models, such …
Human induced pluripotent stem cell-derived lung organoids in an ex vivo model of the congenital diaphragmatic hernia fetal lung
SM Kunisaki, G Jiang, JC Biancotti… - Stem cells …, 2021 - academic.oup.com
Three-dimensional lung organoids (LOs) derived from pluripotent stem cells have the
potential to enhance our understanding of disease mechanisms and to enable novel …
potential to enhance our understanding of disease mechanisms and to enable novel …
Small extracellular vesicles from human amniotic fluid samples as promising theranostics
Since the first evidence that stem cells can provide pro-resolving effects via paracrine
secretion of soluble factors, growing interest has been addressed to define the most ideal …
secretion of soluble factors, growing interest has been addressed to define the most ideal …
Barriers in translating stem cell therapies for neonatal diseases
A Damianos, I Sammour - Seminars in Perinatology, 2023 - Elsevier
Over the last 20 years, stem cells of varying origin and their associated secretome have
been investigated as a therapeutic option for a myriad of neonatal models of disease, with …
been investigated as a therapeutic option for a myriad of neonatal models of disease, with …
Stem cell therapies for neonatal lung diseases: Are we there yet?
B Thébaud - Seminars in Perinatology, 2023 - Elsevier
Lung diseases are a main cause of mortality and morbidity in neonates. Despite major
breakthroughs, therapies remain supportive and, in some instances, contribute to lung …
breakthroughs, therapies remain supportive and, in some instances, contribute to lung …
[HTML][HTML] Cellular origins and translational approaches to congenital diaphragmatic hernia
Abstract Congenital Diaphragmatic Hernia (CDH) is a complex developmental abnormality
characterized by abnormal lung development, a diaphragmatic defect and cardiac …
characterized by abnormal lung development, a diaphragmatic defect and cardiac …