The COP9 signalosome (CSN) is a signaling platform controlling the cellular ubiquitylation
status. It determines the activity and remodeling of~ 700 cullin-RING ubiquitin ligases …

The DNA damage response (DDR) safeguards the stable genetic information inheritance by
orchestrating a complex protein network in response to DNA damage. However, this …

Multiple DNA double-strand break (DSB) repair pathways are active in S phase of the cell
cycle; however, DSBs are primarily repaired by homologous recombination (HR) in this cell …

Genomic instability induced by DNA damage and improper DNA damage repair is one of the
main causes of malignant transformation and tumorigenesis. DNA double strand breaks …

Maintaining stability of the genome requires dedicated DNA repair and signalling processes
that are essential for the faithful duplication and propagation of chromosomes. These DNA …

The maintenance of genomic integrity is an important process in organisms as failure to
sense and repair damaged DNA can result in a variety of diseases. Eukaryotic cells have …

Cullin-RING ligases (CRL) are ubiquitin E3 enzymes that bind substrates through variable
substrate receptor proteins and are activated by attachment of the ubiquitin-like protein …

It is widely accepted that DNA replication fork stalling is a common occurrence during cell
proliferation, but there are robust mechanisms to alleviate this and ensure DNA replication is …

Eukaryotic genome surveillance is dependent on the multiple, highly coordinated network
functions of the DNA damage response (DDR). Highlighted conserved features of DDR in …

Epidemiological and experimental data highlighted the thyroid-disrupting activity of
bisphenol A (BPA). Although pivotal to identify the mechanisms of toxicity, direct low-dose …