[HTML][HTML] Controlling timing and location in vaccines
Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …
immune response induced by immunization arises following appropriate activation and …
Functional T cells are capable of supernumerary cell division and longevity
Differentiated somatic mammalian cells putatively exhibit species-specific division limits that
impede cancer but may constrain lifespans,–. To provide immunity, transiently stimulated …
impede cancer but may constrain lifespans,–. To provide immunity, transiently stimulated …
Developmental plasticity allows outside-in immune responses by resident memory T cells
Central memory T (TCM) cells patrol lymph nodes and perform conventional memory
responses on restimulation: proliferation, migration and differentiation into diverse T cell …
responses on restimulation: proliferation, migration and differentiation into diverse T cell …
The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells
Extracellular ATP (eATP) is an ancient 'danger signal'used by eukaryotes to detect cellular
damage. In mice and humans, the release of eATP during inflammation or injury stimulates …
damage. In mice and humans, the release of eATP during inflammation or injury stimulates …
Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory
CD8+ T cell immunosurveillance dynamics influence the outcome of intracellular infections
and cancer. Here we used two-photon intravital microscopy to visualize the responses of …
and cancer. Here we used two-photon intravital microscopy to visualize the responses of …
T cells in nonlymphoid tissues give rise to lymph-node-resident memory T cells
Immunosurveillance of secondary lymphoid organs (SLO) is performed by central memory T
cells that recirculate through blood. Resident memory T (Trm) cells remain parked in …
cells that recirculate through blood. Resident memory T (Trm) cells remain parked in …
[HTML][HTML] CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses
LK Beura, NJ Fares-Frederickson, EM Steinert… - Journal of Experimental …, 2019 - rupress.org
This study examines the extent to which memory CD4+ T cells share immunosurveillance
strategies with CD8+ resident memory T cells (T RM). After acute viral infection, memory …
strategies with CD8+ resident memory T cells (T RM). After acute viral infection, memory …
Durable CD8 T cell memory against SARS-CoV-2 by Prime/Boost and multi-dose vaccination: Considerations on inter-dose time intervals
A Natalini, S Simonetti, C Sher, U D'Oro… - International Journal of …, 2022 - mdpi.com
Facing the COVID-19 pandemic, anti-SARS-CoV-2 vaccines were developed at
unprecedented pace, productively exploiting contemporary fundamental research and prior …
unprecedented pace, productively exploiting contemporary fundamental research and prior …
Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning
Background Human microbiota-associated (HMA) animal models relying on germ-free
recipient mice are being used to study the relationship between intestinal microbiota and …
recipient mice are being used to study the relationship between intestinal microbiota and …
Lipid-nanoparticle-encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection
CJ Knudson, P Alves-Peixoto, H Muramatsu… - Molecular Therapy, 2021 - cell.com
It is well established that memory CD8 T cells protect susceptible strains of mice from
mousepox, a lethal viral disease caused by ectromelia virus (ECTV), the murine counterpart …
mousepox, a lethal viral disease caused by ectromelia virus (ECTV), the murine counterpart …