The centromere serves as the binding site for the kinetochore and is essential for the faithful
segregation of chromosomes throughout cell division. The point centromere in yeast is …

Background The dynamic properties of microtubules depend on complex nanoscale
structural rearrangements in their end regions. Members of the EB1 and XMAP215 protein …

Transportation-based metrics for comparing images have long been applied to analyze
images, especially where one can interpret the pixel intensities (or derived quantities) as a …

One of the most fundamental concepts of microscopy is that of resolution–the ability to
clearly distinguish two objects as separate. Recent advances such as structured illumination …

Animal cell shape is controlled primarily by the actomyosin cortex, a thin cytoskeletal
network that lies directly beneath the plasma membrane. The cortex regulates cell …

The Saccharomyces cerevisiae mitotic spindle in budding yeast is exemplified by its
simplicity and elegance. Microtubules are nucleated from a crystalline array of proteins …

CAMSAP and Patronin family members regulate microtubule minus-end stability and
localization and thus organize noncentrosomal microtubule networks, which are essential …

Microtubules (MTs) are central to fundamental cellular processes including mitosis,
polarization, and axon extension. A key issue is to understand how MT-associated proteins …

The mechanisms by which sister chromatids maintain biorientation on the metaphase
spindle are critical to the fidelity of chromosome segregation. Active force interplay exists …

During cell division, a mitotic spindle is built by the cell and acts to align and stretch
duplicated sister chromosomes before their ultimate segregation into daughter cells …