Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

Notch signalling links the fate of one cell to that of an immediate neighbour and
consequently controls differentiation, proliferation and apoptotic events in multiple metazoan …

Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a
fundamental role in metazoan development. Signals exchanged between neighboring cells …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Satellite cells (SCs) are myogenic stem cells found in skeletal muscle that function to repair
tissue damaged by injury or disease. SCs are quiescent at rest, although the signaling …

Skeletal muscle stem cells have a central role in muscle growth and regeneration. They
reside as quiescent cells in resting muscle and in response to damage they transiently …

Notch signaling dictates cell fate and critically influences cell proliferation, differentiation,
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …

A hallmark of aging is diminished regenerative potential of tissues, but the mechanism of this
decline is unknown. Analysis of injured muscle revealed that, with age, resident precursor …

While the transmembrane protein Notch plays an important role in various aspects of
development, and diseases including tumors and neurological disorders, the intracellular …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Loss-and gain-of-function studies revealed both the pleiotropic action of the …